This work was supported by Konyang University Myunggok Research Fund of 2009. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Intratympanic dexamethasone injection for refractory tinnitus: Prospective placebo-controlled study
Article first published online: 25 APR 2013
Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 123, Issue 11, pages 2817–2822, November 2013
How to Cite
Choi, S. J., Lee, J. B., Lim, H. J., In, S. M., Kim, J.-Y., Bae, K. H. and Choung, Y.-H. (2013), Intratympanic dexamethasone injection for refractory tinnitus: Prospective placebo-controlled study. The Laryngoscope, 123: 2817–2822. doi: 10.1002/lary.24126
- Issue published online: 28 OCT 2013
- Article first published online: 25 APR 2013
- Manuscript Accepted: 6 MAR 2013
- Manuscript Revised: 19 FEB 2013
- Manuscript Received: 27 SEP 2012
The purpose of this study is to investigate the effectiveness of intratympanic dexamethasone injections (ITDI) for refractory tinnitus.
A prospective, placebo-controlled, randomized, double-blind study.
Thirty patients with refractory tinnitus who were diagnosed in the Department of Otolaryngology, Ajou University Hospital, Suwon, Republic of Korea, between 2006 and 2007 were enrolled and then were assigned into two groups of ITDI (15 patients) or saline (15 patients) by permuted block randomization. Intratympanic injections were double-blind performed four times within 2 weeks. After 4 weeks, we analyzed the improvement and aggravation rates of tinnitus using the following parameters: questionnaires, tinnitus handicap index (THI), loudness matching test, frequency, and duration of tinnitus.
The effectiveness rates of ITDI for refractory tinnitus reported in the tinnitus questionnaires, in the THI, and in the loudness matching test were all 33.3% in the steroid group, and 26.7%, 40.0%, and 26.7% in the saline group, respectively. However, there were no statistically significant differences in both groups. To analyze the therapeutic effect of ITDI on tinnitus under 6 months of its development, the improvement rates reported in the tinnitus questionnaires, in the THI, and in the loudness matching test were all 28.5% in the steroid group, and 40.0%, 40.0%, and 30.0% in the saline group, respectively. There were also no statistically significant differences in both groups.
ITDI may not be effective for refractory tinnitus. The indication of ITDI for tinnitus needs to be limited to specific cases.
Level of Evidence
1b. Laryngoscope, 123:2817–2822, 2013