This study was supported by grants HL 89104, HL 103415, and HL 107745 from the National Institutes of Health. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat
Article first published online: 13 MAY 2013
Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 123, Issue 12, pages 3088–3092, December 2013
How to Cite
Castillo, D. and Pitts, T. (2013), Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat. The Laryngoscope, 123: 3088–3092. doi: 10.1002/lary.24143
- Issue published online: 25 NOV 2013
- Article first published online: 13 MAY 2013
- Manuscript Revised: 18 MAR 2013
- Manuscript Accepted: 18 MAR 2013
- Manuscript Received: 8 JAN 2013
- rectus abdominis;
- posterior cricoid arytenoid;
- upper airway;
The antitussive properties of (±) baclofen on laryngeal muscle activities have not been determined. The hypothesis of this study was that administration of (±) baclofen would suppress upper airway muscle motor activity in a dose-dependent manner during cough.
This is a prospective, preclinical, hypothesis-driven, paired design.
Electromyograms of the parasternal, rectus abdominis, thyroarytenoid, posterior cricoarytenoid, and thyrohyoid were measured, along with esophageal pressure. Cough was elicited by mechanical stimulation of the lumen of the intrathoracic trachea in spontaneously breathing cats.
Baclofen (±) (3–10 μg kg−1 i.a.) induced decreases in the electromyogram amplitude of the rectus abdominis motor drive during coughing, the inspiratory and active expiratory (E1) phases of cough, and cough number per epoch. There was no effect of (±) baclofen on the EMG amplitudes of any of the laryngeal muscles, the parasternal, or the duration of the passive expiratory (E2) phase.
Results from the present study indicate differential control mechanisms for laryngeal and inspiratory motor drive during cough, providing evidence of a control system regulating laryngeal activity and inspiratory spinal drive that is divergent from the control of expiratory spinal motoneurons.
Level of Evidence
N/A. Laryngoscope, 123:3088–3092, 2013