Get access

Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat

Authors

  • Daniel Castillo BS,

    1. Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, U.S.A
    Search for more papers by this author
  • Teresa Pitts PhD

    Corresponding author
    1. Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, U.S.A
    • Send correspondence to Teresa Pitts, PhD, PO Box 100144, Gainesville, FL 32610-0144. E-mail: tepitts@ufl.edu

    Search for more papers by this author

  • This study was supported by grants HL 89104, HL 103415, and HL 107745 from the National Institutes of Health. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis

The antitussive properties of (±) baclofen on laryngeal muscle activities have not been determined. The hypothesis of this study was that administration of (±) baclofen would suppress upper airway muscle motor activity in a dose-dependent manner during cough.

Study Design

This is a prospective, preclinical, hypothesis-driven, paired design.

Methods

Electromyograms of the parasternal, rectus abdominis, thyroarytenoid, posterior cricoarytenoid, and thyrohyoid were measured, along with esophageal pressure. Cough was elicited by mechanical stimulation of the lumen of the intrathoracic trachea in spontaneously breathing cats.

Results

Baclofen (±) (3–10 μg kg−1 i.a.) induced decreases in the electromyogram amplitude of the rectus abdominis motor drive during coughing, the inspiratory and active expiratory (E1) phases of cough, and cough number per epoch. There was no effect of (±) baclofen on the EMG amplitudes of any of the laryngeal muscles, the parasternal, or the duration of the passive expiratory (E2) phase.

Conclusions

Results from the present study indicate differential control mechanisms for laryngeal and inspiratory motor drive during cough, providing evidence of a control system regulating laryngeal activity and inspiratory spinal drive that is divergent from the control of expiratory spinal motoneurons.

Level of Evidence

N/A. Laryngoscope, 123:3088–3092, 2013

Ancillary