Presented at the Triological Society Combined Sections Meeting, January 26, 2013, Scottsdale, Arizona, U.S.A.
Aspirin sensitivity does not compromise quality-of-life outcomes in patients with samter's triad
Article first published online: 28 JUN 2013
© 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 124, Issue 1, pages 34–37, January 2014
How to Cite
Jang, D. W., Comer, B. T., Lachanas, V. A. and Kountakis, S. E. (2014), Aspirin sensitivity does not compromise quality-of-life outcomes in patients with samter's triad. The Laryngoscope, 124: 34–37. doi: 10.1002/lary.24220
The authors have no funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 20 DEC 2013
- Article first published online: 28 JUN 2013
- Accepted manuscript online: 27 MAY 2013 09:08AM EST
- Manuscript Accepted: 1 MAY 2013
- Manuscript Revised: 2 FEB 2013
- Manuscript Received: 2 JAN 2013
- Chronic rhinosinusitis;
- nasal polyposis;
- Samter's triad;
- aspirin sensitivity
To demonstrate that quality-of-life outcomes after endoscopic sinus surgery are not compromised in patients with Samter's triad (asthma, nasal polyps, aspirin sensitivity) when compared to patients with eosinophilic chronic rhinosinusitis with nasal polyposis (eCRSwP) who are not aspirin sensitive.
Retrospective review of prospectively collected data.
Thirty-two patients with Samter's triad were identified from a prospectively collected patient database from 2003 to 2012. Preoperative and postoperative symptom and endoscopy scores were compared to those of 37 consecutive patients with eCRSwP who were not aspirin sensitive (control). Student t test and Fisher exact test were used to examine for differences between the two groups. Symptom scores were assessed using the 20-item Sino-Nasal Outcome Test (SNOT-20). Endoscopy findings were scored according to the Lund-Kennedy methodology.
Samter's triad patients had significantly worse disease preoperatively when compared to the control group: SNOT-20 (31.1 vs. 22.1, P = .004), endoscopy score (10.9 vs. 7.6, P = .0005), and Lund-Mackay computed tomography score (18.9 vs. 13.9, P = .0001). Although postoperative endoscopy scores remained worse in the Samter's triad group, postoperative SNOT-20 scores were comparable to those of the control group at ≥3 years follow-up (22.8 vs. 17.3, P = .43).
Although Samter's triad patients present with more severe disease and are more likely to undergo revision surgery, they have postoperative quality-of-life outcomes that are comparable to patients with eCRSwP who are not aspirin sensitive. This is the first study to utilize a disease-specific, validated outcomes instrument in comparing Samter's triad patients with aspirin-tolerant patients who have nasal polyposis and tissue eosinophilia.
Level of Evidence
4. Laryngoscope, 124:34–37, 2014