Cricothyroid muscle dysfunction impairs vocal fold vibration in unilateral vocal fold paralysis

Authors

  • Yu-Cheng Pei MD, PhD,

    1. Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
    2. School of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
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  • Tuan-Jen Fang MD,

    Corresponding author
    1. School of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
    2. Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
    • Send correspondence to Tuan-Jen Fang, MD, No. 5 Fushing St., Taoyuan 333, Taiwan. E-mail: fang3109@cgmh.org.tw

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  • Hsueh-Yu Li MD,

    1. School of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
    2. Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
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  • Alice M. K. Wong MD

    1. Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
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  • Presented at the 8th East Asia Conference on Phonosurgery, Jeju Island, Korea, November 30–December 1, 2012.

  • This work was supported by a National Science Council grant (NSC 100–2314-B-182-021). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

  • The authors have no other funding, financial relationships, or conflicts of interest to disclose.

  • y.-c.p. and t.-j.f. conceived and designed the experiments, performed the experiments, and wrote the manuscript. All of the authors contributed materials and analysis tools.

Abstract

Objectives/Hypothesis

The relevance of the cricothyroid (CT) muscle in patients with unilateral vocal fold paralysis (UVFP) remains controversial. To clarify the functional significance of the CT muscle in patients with UVFP, the confounding effect of the severity of recurrent laryngeal nerve injury should be taken into consideration. In the present study, quantitative laryngeal electromyography (LEMG) was used to measure the severity of paralysis of the thyroarytenoid-lateral cricoarytenoid (TA-LCA) muscle complex to allow the functional contribution of the CT muscle to be determined.

Study Design

Cross-sectional study performed in an otolaryngology outpatient clinic.

Methods

Thirty-one patients with a main diagnosis of UVFP were recruited. The main outcome measures included LEMG examination, quantitative LEMG analysis of the TA-LCA muscle complex, UVFP-related quality-of-life questionnaire (Voice Outcome Survey [VOS]), voice acoustics analysis, videolaryngostroboscopy, and general quality-of-life questionnaire (Short Form-36 Health Survey [SF-36]) assessments.

Results

The vocal cord position did not differ between patients with and without CT muscle impairment. Patients with both TA-LCA and CT paralysis showed poorer vocal fold vibration (P = .048) and higher fundamental frequency (P = .02), and the VOS and SF-36 were both poorer compared with patients with only TA-LCA paralysis.

Conclusions

Although the vocal cord position was not influenced by CT muscle function, coexisting CT muscle paralysis may damage the voice by impairing vocal fold vibration in UVFP patients.

Level of Evidence

4. Laryngoscope, 124:201–206, 2014

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