Demographic trends and disease-specific survival in salivary acinic cell carcinoma: An analysis of 1129 cases

Authors

  • Neal R. Patel BS,

    1. Department of Otolaryngology–Head & Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A
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  • Saurin Sanghvi MD,

    1. Department of Otolaryngology–Head & Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A
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  • Mohemmed N. Khan MD,

    1. Department of Otolaryngology–Head & Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A
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  • Qasim Husain MD,

    1. Department of Otolaryngology–Head & Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A
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  • Soly Baredes MD, FACS,

    1. Department of Otolaryngology–Head & Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A
    2. Department of Neurological Surgery, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, U.S.A
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  • Jean Anderson Eloy MD, FACS

    Corresponding author
    1. Department of Otolaryngology–Head & Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A
    2. Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A
    3. Department of Neurological Surgery, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, U.S.A
    • Send correspondence to Jean Anderson Eloy, MD, FACS, Associate Professor and Vice Chairman, Director of Rhinology and Sinus Surgery, Department of Otolaryngology–Head and Neck Surgery, UMDNJ-New Jersey Medical School, 90 Bergen St., Suite 8100, Newark, NJ 07103. E-mail: jean.anderson.eloy@gmail.com

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  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objective/Hypothesis

Acinic cell carcinoma (AciCC) is a rare salivary gland malignancy that most commonly arises in the parotid gland. Characteristics of AciCC are slow growth and a long clinical course. As a rare tumor, population-based studies are limited. We analyzed the incidence and survival for AciCC using a national population-based database.

Study Design

Retrospective analysis.

Methods

The United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to calculate incidence and disease-specific survival trends for AciCC between 1973 and 2009. Patient data were stratified according to age, gender, race, grade, and extent of disease. Incidence trends were studied across the last 30 years and long-term disease-specific survival outcomes were compared across the different demographic parameters.

Results

A total of 1,129 cases of AciCC were identified, comprising of 672 (59.52%) females. Incidence trend analysis revealed significant changes in yearly incidence rates from 1973 to 2009 for male gender and white and “others” races. Overall 5-year survival was 97.15%, 10-year survival was 93.81%, and 20-year survival was 89.74%. Significant differences in survival outcomes were noted for extent of disease. Patients exhibiting distant metastasis displayed the worse long-term prognosis at 21.99% 20-year disease-specific survival. Hazard ratios demonstrated a significant increase in mortality in patients with poorly differentiated, undifferentiated, and metastatic disease.

Conclusion

Trends in incidence of AciCC are influenced by gender, race and age. Long-term survival of this rare malignant tumor is influenced by gender, grade, race, and extent of disease. Future studies need to be conducted to investigate these dynamic trends related to AciCC.

Level of Evidence

2b. Laryngoscope, 124:172–178, 2014

Ancillary