• 1
    Rabik CA, Dolan ME. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 2007;33:923.
  • 2
    Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003;22:72657279.
  • 3
    Coradini PP, Cigana L, Selistre SG, Rosito LS, Brunetto AL. Ototoxicity from cisplatin therapy in childhood cancer. J Pediatr Hematol Oncol 2007;29:355360.
  • 4
    Laurell G, Beskow C, Frankendal B, Borg E. Cisplatin administration to gynecologic cancer patients. Long-term effects on hearing. Cancer 1996;78:17981804.
  • 5
    Laurell G, Jungnelius U. High-dose cisplatin treatment: hearing loss and plasma concentrations. Laryngoscope 1990;100:724734.
  • 6
    Hannigan EV, Green S, Alberts DS, O'Toole R, Surwit E. Results of a Southwest Oncology Group phase III trial of carboplatin plus cyclophosphamide versus cisplatin plus cyclophosphamide in advanced ovarian cancer. Oncology 1993;50(suppl 2):29.
  • 7
    Cavaletti G, Bogliun G, Crespi V, et al. Neurotoxicity and ototoxicity of cisplatin plus paclitaxel in comparison to cisplatin plus cyclophosphamide in patients with epithelial ovarian cancer. J Clin Oncol 1997;15:199206.
  • 8
    Rademaker-Lakhai JM, Crul M, Zuur L, et al. Relationship between cisplatin administration and the development of ototoxicity. J Clin Oncol 2006;24:918924.
  • 9
    Laurell G, Ekborn A, Viberg A, Canlon B. Effects of a single high dose of cisplatin on the melanocytes of the stria vascularis in the guinea pig. Audiol Neurootol 2007;12:170178.
  • 10
    Mandic A, Hansson J, Linder S, Shoshan MC. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 2003;278:91009106.
  • 11
    Kim HJ, Lee JH, Kim SJ, et al. Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity. J Neurosci 2010;30:39333946.
  • 12
    Yachnin JR, Wallin I, Lewensohn R, Sirzen F, Ehrsson H. The kinetics and cytotoxicity of cisplatin and its monohydrated complex. Cancer Lett 1998;132:175180.
  • 13
    Ekborn A, Lindberg A, Laurell G, Wallin I, Eksborg S, Ehrsson H. Ototoxicity, nephrotoxicity and pharmacokinetics of cisplatin and its monohydrated complex in the guinea pig. Cancer Chemother Pharmacol 2003;51:3642.
  • 14
    Laurell G, Andersson A, Engstrom B, Ehrsson H. Distribution of cisplatin in perilymph and cerebrospinal fluid after intravenous administration in the guinea pig. Cancer Chemother Pharmacol 1995;36:8386.
  • 15
    Hellberg V, Wallin I, Eriksson S, et al. Cisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicity. J Natl Cancer Inst 2009;101:3747.
  • 16
    Salt AN, Hale SA, Plonkte SK. Perilymph sampling from the cochlear apex: a reliable method to obtain higher purity perilymph samples from scala tympani. J Neurosci Methods 2006;153:121129.
  • 17
    Thorne M, Salt AN, DeMott JE, Henson MM, Henson OW Jr, Gewalt SL. Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images. Laryngoscope 1999;109:16611668.
  • 18
    Shinomori Y, Spack DS, Jones DD, Kimura RS. Volumetric and dimensional analysis of the guinea pig inner ear. Ann Otol Rhinol Laryngol 2001;110:9198.
  • 19
    Mynatt R, Hale SA, Gill RM, Plontke SK, Salt AN. Demonstration of a longitudinal concentration gradient along scala tympani by sequential sampling of perilymph from the cochlear apex. J Assoc Res Otolaryngol 2006;7:182193.
  • 20
    Reiber H, Schunck O. Suboccipital puncture of guinea pigs. Lab Anim 1983;17:2527.
  • 21
    Pierre PV, Wallin I, Eksborg S, Ehrsson H. Quantitative liquid chromatographic determination of intact cisplatin in blood with microwave-assisted post-column derivatization and UV detection. J Pharm Biomed Anal 2011;56:126130.
  • 22
    Ciarimboli G, Deuster D, Knief A, et al. Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol 2010;176:11691180.
  • 23
    Tran Ba Huy P, Bernard P, Schacht J. Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs. J Clin Invest 1986;77:14921500.
  • 24
    Stepanyan RS, Indzhykulian AA, Velez-Ortega AC, et al. TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells. J Assoc Res Otolaryngol 2011;12:729740.
  • 25
    Andersson A, Ehrsson H. Stability of cisplatin and its monohydrated complex in blood, plasma and ultrafiltrate—implications for quantitative analysis. J Pharm Biomed Anal 1995;13:639644.
  • 26
    Ehrsson H, Wallin I. Liquid chromatographic determination of oxaliplatin in blood using post-column derivatization in a microwave field followed by photometric detection. J Chromatogr B Analyt Technol Biomed Life Sci 2003;795:291294.
  • 27
    Cohen-Salmon M, Regnault B, Cayet N, et al. Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci USA 2007;104:62296234.
  • 28
    Jahnke K. The blood-perilymph barrier. Arch Otorhinolaryngol 1980;228:2934.
  • 29
    Juhn SK, Hunter BA, Odland RM. Blood-labyrinth barrier and fluid dynamics of the inner ear. Int Tinnitus J 2001;7:7283.
  • 30
    Neng L, Zhang F, Kachelmeier A, Shi X. Endothelial cell, pericyte, and perivascular resident macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability. J Assoc Res Otolaryngol 2013;14:175185.
  • 31
    Laurell G, Teixeira M, Sterkers O, Ferrary E. Paracellular transport properties of inner ear barriers do not account for cisplatin toxicity in the rat. Hear Res 1997;110:135140.
  • 32
    Li Y, Ding D, Jiang H, Fu Y, Salvi R. Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice. Neurotox Res 2011;20:307319.
  • 33
    Hirt B, Penkova ZH, Eckhard A, et al. The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph-endolymph barrier. Neuroscience 2010;168:957970.
  • 34
    Li H, Steyger PS. Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. Sci Rep 2011;1:159.
  • 35
    Papakostas K, Hackney CM, Furness DN. The distribution of the calcium buffer calbindin in the cochlea of the guinea-pig. Otolaryngol Allied Sci 2000;25:570576.
  • 36
    Choung YH, Taura A, Pak K, Choi SJ, Masuda M, Ryan AF. Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience 2009;161:214226.
  • 37
    Salt AN, Kellner C, Hale S. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear Res 2003;182:2433.
  • 38
    He J, Yin S, Wang J, Ding D, Jiang H. Effectiveness of different approaches for establishing cisplatin-induced cochlear lesions in mice. Acta Otolaryngol 2009;129:13591367.
  • 39
    Xia L, Chen Z, Yin S. Ototoxicity of cisplatin administered to guinea pigs via the round window membrane. J Toxicol Sci 2012;37:823830.
  • 40
    Steyger PS, Karasawa T. Intra-cochlear trafficking of aminoglycosides. Commun Integr Biol 2008;1:140142.
  • 41
    More SS, Li S, Yee SW, et al. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther 2010;9:10581069.
  • 42
    Howell SB, Safaei R, Larson CA, Sailor MJ. Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol 2010;77:887894.
  • 43
    Ding D, He J, Allman BL, et al. Cisplatin ototoxicity in rat cochlear organotypic cultures. Hear Res 2011;282:196203.
  • 44
    Ekborn A, Laurell G, Andersson A, Wallin I, Eksborg S, Ehrsson H. Cisplatin-induced hearing loss: influence of the mode of drug administration in the guinea pig. Hear Res 2000;140:3844.
  • 45
    Ekborn A, Laurell G, Johnstrom P, Wallin I, Eksborg S, Ehrsson H. D-Methionine and cisplatin ototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics. Hear Res 2002;165:5361.
  • 46
    Konishi T, Salt AN, Hamrick PE. Effects of exposure to noise on ion movement in guinea pig cochlea. Hear Res 1979;1:325342.
  • 47
    Saliba I, El Fata F, Ouelette V, Robitaille Y. Are intratympanic injections of N-acetylcysteine and methylprednisolone protective against Cisplatin-induced ototoxicity? J Otolaryngol Head Neck Surg 2010;39:236243.
  • 48
    Murphy D, Daniel SJ. Intratympanic dexamethasone to prevent cisplatin ototoxicity: a guinea pig model. Otolaryngol Head Neck Surg 2011;145:452457.
  • 49
    Berglin CE, Pierre PV, Bramer T, et al. Prevention of cisplatin-induced hearing loss by administration of a thiosulfate-containing gel to the middle ear in a guinea pig model. Cancer Chemother Pharmacol 2011;68:15471556.