Presented at the Triological Society 2013 Combined Sections Meeting, Scottsdale, Arizona, U.S.A., January 24, 2013.
Head and Neck
Bone morphogenetic protein 6 expression in oral cavity squamous cell cancer is associated with bone invasion
Article first published online: 1 JUL 2013
Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 123, Issue 12, pages 3061–3065, December 2013
How to Cite
Kejner, A. E., Burch, M. B., Sweeny, L. and Rosenthal, E. L. (2013), Bone morphogenetic protein 6 expression in oral cavity squamous cell cancer is associated with bone invasion. The Laryngoscope, 123: 3061–3065. doi: 10.1002/lary.24267
This work was supported by a grant from the National Institutes of Health R01CA142637-0A1 and National Cancer Institute 5R25CA76023. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 25 NOV 2013
- Article first published online: 1 JUL 2013
- Accepted manuscript online: 17 JUN 2013 12:22PM EST
- Manuscript Revised: 29 MAY 2013
- Manuscript Accepted: 29 MAY 2013
- Head and neck;
- bone morphogenetic protein-6;
- tumor biomarkers;
- oral cavity cancer;
- squamous cell carcinoma
To evaluate bone invasion, survival, and expression of bone morphogenetic protein-6 (BMP-6) in oral cavity cancer in the context of known biomarkers indicative of poor prognosis.
Molecular expression study combined with retrospective chart review of corresponding patients at a tertiary care center.
Between 2000 and 2009, a total of 197 patients underwent resection for oral cavity squamous cell carcinoma. Of these, 30 pathologic specimens were chosen for further molecular analysis. These 30 patients were separated into three groups (10 per group) based on American Joint Committee on Cancer (AJCC) staging and staging based on size alone (TAJCC/SIZE). The first group consisted of tumors staged as T2/2 based on size less than 4 cm and that had no evidence of bone invasion. The T2/4 group consisted of tumors that were upstaged from T2 based on bone invasion. The T4/4 group consisted of tumors that were large with and without bone invasion. The expression of extracellular matrix metalloproteinase inducer (EMMPRIN), BMP-6, and epidermal growth factor receptor (EGFR) was examined using immunohistochemistry techniques. Patient demographics, tumor characteristics, survival, and recurrence were compared.
Average follow-up was 21 months. Expression of BMP-6 was significantly higher in the T2/4 cohort (tumor less than 4 cm with bony invasion) than the larger tumors without bone invasion (T4/4 cohort, P = .05). In addition, increased BMP-6 expression correlated with aggressive behavior in the smaller tumors. Furthermore, increased EGFR expression positively correlated with increased levels of BMP-6.
Increased expression of BMP-6 in oral cavity cancer may affect bone invasion.
Level of Evidence
N/A. Laryngoscope, 123:3061–3065, 2013