Endothelin-1 gene polymorphism in sudden sensorineural hearing loss

Authors

  • Yasue Uchida MD, PhD,

    Corresponding author
    1. Department of Otorhinolaryngology, Aichi Medical University, Nagakute, Aichi, Japan
    2. Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan
    • Address correspondence to: Yasue Uchida, MD, Department of Otorhinolaryngology, Aichi Medical University, Nagakute, Aichi, 480–1195 Japan. E-mail: yasueu@aichi-med-u.ac.jp

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  • Masaaki Teranishi MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    2. Department of Health and Medical Sciences, Aichi Shukutoku University, Aichi, Japan
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  • Naoki Nishio MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Saiko Sugiura MD, PhD,

    1. Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan
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  • Mariko Hiramatsu MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Hidenori Suzuki MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    2. Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Japan
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  • Ken Kato MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Hironao Otake MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Tadao Yoshida MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Mitsuhiko Tagaya MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    2. Department of Otorhinolaryngology, Tosei General Hospital, Seto, Aichi, Japan
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  • Hirokazu Suzuki MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    2. Department of Health and Medical Sciences, Aichi Shukutoku University, Aichi, Japan
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  • Michihiko Sone MD, PhD,

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Fujiko Ando MD, PhD,

    1. Department of Health and Medical Sciences, Aichi Shukutoku University, Aichi, Japan
    2. Department for Development of Preventive Medicine, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi, Japan
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  • Hiroshi Shimokata MD, PhD,

    1. Department for Development of Preventive Medicine, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi, Japan
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  • Tsutomu Nakashima MD, PhD

    1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • Presented orally at the First Asian Otology Meeting and the Third East Asian Symposium on Otology, Nagasaki, Japan, June 3, 2012.

  • This study was supported in part by the Research Grant for Longevity Sciences (20shi-2), by the Research Grant for Longevity Sciences (21A-17, H20-Nanchi-021) from the Ministry of Health, Labour, and Welfare, and by research grants (21390460, 20591979) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis

Endothelin-1 is a potent vasoconstrictor peptide that is widely distributed throughout the mammalian body including the spiral modiolar artery, vestibule, and cochlea. This study aimed to investigate the association between the Lys198Asn (G/T) polymorphism (rs5370) of the endothelin-1 gene and sudden sensorineural hearing loss (SSNHL).

Study Design

Case-control study.

Methods

Seventy-two SSNHL patients (mean age, 58.3 ± 14.0 years) were compared with 2,159 controls included in a community-based study of aging. Multiple logistic regression was used to obtain odds ratios (ORs) for SSNHL. In subgroup analysis, patients with SSNHL who visited to the hospital within the first month of onset were selected to assess audiometric features according to genotype. Pure-tone averages at 250, 500, 1,000, 2,000, and 4,000 Hz were calculated in the affected ear.

Results

Under the recessive genetic model, after adjustment for age, sex, histories of hypertension, dyslipidemia and diabetes, the crude and adjusted ORs for SSNHL risk were 2.209 (95% confidence interval [CI]: 1.140-4.281) and 2.173 (95% CI: 1.086-4.348), respectively. No significant ORs were observed under the additive and dominant models. The severity of SSNHL differed significantly between genotypes. The mean pure-tone averages at the initial visit were 78.6, 66.4, and 57.8 dB for the GG, GT, and TT genotypes, respectively (P = .034).

Conclusions

Our study indicates that the recessive genotype was significantly associated with increased SSNHL risk; however, the severity was lower in these individuals than it was in those with the wild-type genotype. Endothelin-1 may be implicated in SSNHL.

Level of Evidence

3b Laryngoscope, 123:E59–E65, 2013

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