Dr. Shapiro is a consultant for Arthrocare.
Epstein-barr DNA serology and positron-emission tomography imaging of the head and neck in pediatric transplant recipients
Article first published online: 17 DEC 2013
© 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 124, Issue 5, pages 1236–1241, May 2014
How to Cite
Sidell, D., Venick, R. S. and Shapiro, N. L. (2014), Epstein-barr DNA serology and positron-emission tomography imaging of the head and neck in pediatric transplant recipients. The Laryngoscope, 124: 1236–1241. doi: 10.1002/lary.24376
The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 18 APR 2014
- Article first published online: 17 DEC 2013
- Accepted manuscript online: 18 SEP 2013 04:50AM EST
- Manuscript Revised: 31 JUL 2013
- Manuscript Accepted: 31 JUL 2013
- post-transplantation lymphoproliferative disorder;
- positron-emission tomography;
Epstein-Barr virus (EBV) infection is a potential precursor of post-transplantation lymphoproliferative disorder (PTLD) in the pediatric transplant patient. Positron-emission tomography (PET) imaging is increasingly utilized in this population to monitor for neoplasia and PTLD. We assess the association between EBV serum titers and Waldeyer's ring and cervical lymph node PET positivity in the pediatric transplant recipient.
Retrospective analysis of EBV serology and PET imaging results in pediatric orthotopic liver transplantation (OLT) recipients.
Imaging results and laboratory data were reviewed for all pediatric OLT recipients from January 2005 to July 2011 at a single institution. Charts were evaluated for PET positivity at Waldeyer's ring or cervical lymphatics, and for EBV serology results. Demographic data extracted include patient sex and age at transplantation.
A total of 122 pediatric OLT recipients were reviewed. Twelve patients (10%) underwent PET imaging. Overall, four patients (33%) had evidence of PET positivity at Waldeyer's ring or cervical lymphatics. Five patients (42%) had positive EBV serology. There was a significant association between PET imaging results and EBV DNA serology results (P = .01).
PTLD surveillance in the pediatric transplant recipient is an important component of long-term care in this population. Although PET imaging is a new modality in monitoring pediatric transplant recipients for early signs of PTLD, an association between EBV serology and PET imaging results appears to exist. With increased implementation, PET imaging will likely prove valuable in its ability to monitor the transplant recipient at risk for PTLD.
Level of Evidence
4 Laryngoscope, 124:1236–1241, 2014