This work was supported by the PhD research fund of Zhengzhou University. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Correlation between bacterial biofilms and osteitis in patients with chronic rhinosinusitis
Version of Record online: 7 NOV 2013
© 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 124, Issue 5, pages 1071–1077, May 2014
How to Cite
Dong, D., Yulin, Z., Xiao, W., Hongyan, Z., Jia, L., Yan, X. and Jia, W. (2014), Correlation between bacterial biofilms and osteitis in patients with chronic rhinosinusitis. The Laryngoscope, 124: 1071–1077. doi: 10.1002/lary.24424
- Issue online: 18 APR 2014
- Version of Record online: 7 NOV 2013
- Accepted manuscript online: 1 OCT 2013 09:25AM EST
- Manuscript Accepted: 6 SEP 2013
- Manuscript Revised: 12 AUG 2013
- Chronic rhinosinusitis;
- confocal scanning laser microscopy
Bacterial biofilms (BBF) and osteitis are potential contributors to the local inflammatory load in chronic rhinosinusitis (CRS). This study investigated the relationship between BBF and osteitis status in CRS patients.
Prospective cohort study.
Eighty-four CRS patients undergoing endoscopic sinus surgery and 22 control patients were enrolled in this study. Mucosal and bony samples from ethmoid sinus were obtained for confocal scanning laser microscopy and microscopic examination. Biofilm volume (BV), biofilm score (BS), histopathologic bony grade, Global Osteitis Scoring Scale (GOSS) score, and Hounsfield unit (HU) value on computed tomography were recorded. Associations between these parameters describing BBF and osteitis were assessed.
The histopathologic bony grade 2 (0–3) versus 0 (0–3) (P < 0.001), GOSS score 4.5 (0–31) versus 0 (0–26) (P = 0.014) and HU value 431.5 (310–509) versus 354 (288–499) (P < 0.001) in patients with BBF were greater than those without BBF. The bony grade (r = 0.683, P < 0.001 and r = 0.664, P < 0.001), GOSS score (r = 0.314, P = 0.004 and r = 0.312, P = 0.004), and HU value (r = 0.539, P < 0.001 and r = 0.520, P < 0.001) were significantly increased with higher BV and BS.
A total of 84.8% of the bone underlying mucosa with BBF had some form of osteitis in ethmoid sinus, and approximately 46.4% of CRS patients were from a subgroup with both BBF and osteitis. The volume of BBF correlated well with severity of osteitis in CRS patients.
Level of Evidence
3b. Laryngoscope, 124:1071–1077, 2014