The authors have no funding, financial relationships, or conflicts of interest to disclose.
Facial Plastics/Reconstructive Surgery
Effects of botulinum toxin A on patient-specific keloid fibroblasts in vitro
Article first published online: 13 NOV 2013
© 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 124, Issue 6, pages 1344–1351, June 2014
How to Cite
Haubner, F., Leyh, M., Ohmann, E., Sadick, H. and Gassner, H. G. (2014), Effects of botulinum toxin A on patient-specific keloid fibroblasts in vitro. The Laryngoscope, 124: 1344–1351. doi: 10.1002/lary.24456
- Issue published online: 27 MAY 2014
- Article first published online: 13 NOV 2013
- Accepted manuscript online: 4 OCT 2013 08:19AM EST
- Manuscript Accepted: 26 SEP 2013
- Manuscript Revised: 7 SEP 2013
- Manuscript Received: 20 JUL 2013
- botulinum toxin;
To test whether therapeutic effects of botulinum toxin A on patient- specific keloid tissue can be reproduced on the cellular level. Specifically, effects on cell proliferation and expression of growth factors and cytokines relevant for wound healing were to be tested.
Experimental study including patient specific cell cultures of keloids.
Patient-specific keloid tissue was tested in a cell culture model for effects of botulinum toxin incubation on cell proliferation and expression of the following cytokines and growth factors: IL-6 (interleukin-6), VEGF (vascular endothelial growth factor), TGF-β (transforming growth factor-β).
None of the tested parameters of human keloid tissue were affected by botulinum toxin A incubation.
The present study does not add evidence to suggest a significant therapeutic role of botulinum toxin injections for the treatment of keloids.
Level of Evidence
N/A. Laryngoscope, 124:1344–1351, 2014