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Application of an electronic nose in the diagnosis of head and neck cancer

Authors

  • Nicoline Leunis MD,

    1. Department of Otolaryngology–Head and Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
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  • Marie-Louise Boumans,

    1. Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands
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  • Bernd Kremer MD, PhD,

    1. Department of Otolaryngology–Head and Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
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  • Sinh Din MD,

    1. Department of Otolaryngology–Head and Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
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  • Ellen Stobberingh MD, PhD,

    1. Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands
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  • Alfons G. H. Kessels PhD,

    1. Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, The Netherlands
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  • Kenneth W. Kross MD, PhD

    Corresponding author
    1. Department of Otolaryngology–Head and Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    • Send correspondence to Kenneth W. Kross, MD, PhD, Department of Otolaryngology–Head and Neck Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229HX, Maastricht, The Netherlands. E-mail: Kenneth.kross@mumc.nl

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  • Presented at the 82th meeting of the German Society for Otolaryngology–Head and Neck Surgery, Freiburg, Germany, June 1, 2011; and the 22th meeting of the Scandinavian Society for Head and Neck Oncology, Bergen, Norway, May 3, 2011.

  • The authors have no funding, financial relationships, or conflicts of interest to disclose.

Abstract

Objectives/Hypothesis

Electronic nose (E-nose) technology has various applications such as the monitoring of air quality and the detection of explosive and chemical agents. We studied the diagnostic accuracy of volatile organic compounds (VOC) pattern analysis in exhaled breath by means of an E-nose in patients with head and neck squamous cell carcinoma (HNSCC).

Study Design

Cohort study. Exhaled breath samples from patients with HNSCC were analyzed by using an E-Nose.

Methods

Thirty-six patients diagnosed with HNSCC exhaled into a 5-litre Tedlar bag. The control group consisted of 23 patients visiting the outpatient clinic for other (benign) conditions. Air samples were analyzed using an E-nose.

Results

Logistic regression showed a significant difference (P < 0.05) in VOC resistance patterns between patients diagnosed with HNSCC and the control group, with a sensitivity of 90% and a corresponding specificity of 80%.

Conclusions

E-nose application holds a promising potential for application in the diagnosis of HNSCC due to its rapid, simple, and noninvasive nature.

Level of Evidence

3b. Laryngoscope, 124:1377–1381, 2014

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