The authors have no funding, financial relationships, or conflicts of interest to disclose.
Head and Neck
Is sentinel lymph node biopsy the standard of care for cutaneous head and neck melanoma?
Version of Record online: 1 JUL 2014
© 2014 The American Laryngological, Rhinological and Otological Society, Inc.
Volume 125, Issue 1, pages 153–160, January 2015
How to Cite
Schmalbach, C. E. and Bradford, C. R. (2015), Is sentinel lymph node biopsy the standard of care for cutaneous head and neck melanoma?. The Laryngoscope, 125: 153–160. doi: 10.1002/lary.24807
- Issue online: 24 DEC 2014
- Version of Record online: 1 JUL 2014
- Manuscript Accepted: 6 JUN 2014
- Manuscript Revised: 3 JUN 2014
- Manuscript Received: 22 APR 2014
- Cutaneous melanoma;
- sentinel node
Sentinel lymph node biopsy (SLNB) is considered one of the most important melanoma advancements to date. Since its inception in 1992, a plethora of data and associated controversies has emerged leading to the question: Is SLNB considered the standard of care for head and neck (HN) cutaneous melanoma?
English literature (1990–2014) review.
The PubMed database search was conducted using key terms “melanoma” and “sentinel node.” This review included both dedicated HN SLNB studies and larger prospective SLNB studies, in which HN patients were included among the cohort. Bibliography cross-referencing was conducted to ensure a comprehensive search.
SLNB is safe and accurate in the HN region. Review of large prospective SLNB trials identified the pathologic status of the SLN as the most important prognostic factor for recurrence and survival. Early lymphadenectomy following a positive SLNB imparts a survival benefit.
Our review of the current literature suggests that SLNB is the standard of care for selected cases of HN cutaneous melanoma. It is now incorporated into the American Joint Committee on Cancer staging system, the National Comprehensive Cancer Network practice guidelines, and numerous national and international consensus statements. Laryngoscope, 125:153–160, 2015