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Recent advances in bioluminescence tomography: methodology and system as well as application

Authors

  • Chenghu Qin,

    1. Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    2. Bureau of Academy-Locality Cooperation, Chinese Academy of Sciences, Beijing, China
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    • Contributed equally to this review.

  • Jinchao Feng,

    1. College of Electronic Information and Control Engineering, Beijing University of Technology, Beijing, China
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    • Contributed equally to this review.

  • Shouping Zhu,

    1. Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China
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    • Contributed equally to this review.

  • Xibo Ma,

    1. Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
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    • Contributed equally to this review.

  • Jianghong Zhong,

    1. Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
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  • Ping Wu,

    1. Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
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  • Zhengyu Jin,

    1. Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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  • Jie Tian

    Corresponding author
    1. Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    2. Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China
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Errata

This article is corrected by:

  1. Errata: Recent advances in bioluminescence tomography: methodology and system as well as application Volume 9, Issue 1, Article first published online: 1 October 2012

Abstract

Optical molecular imaging has been rapidly developed to noninvasively visualize in vivo physiological and pathological processes involved in normal and suffering organisms at the cellular and molecular levels, in which advanced optical imaging technology and modern molecular biology are being combined to provide a state-of-the-art tool for preclinical biomedical research. Among optical molecular imaging modalities, bioluminescence tomography (BLT) has experienced considerable growth and attracted much attention in recent years for its excellent performance, unique advantages, and high cost-effectiveness. This article focuses on the genesis and development of BLT, especially for its computational methodology, imaging system, and biomedical application. An overview of the advantages and challenges of the conventional planar bioluminescence imaging technique is first described in comparison with currently available molecular imaging modalities. The imaging algorithms for inverse source reconstruction are classified and summarized according to different a priori knowledge, followed by a simple depiction of the uniqueness theorems of BLT solution. Diverse imaging systems for obtaining three-dimensional quantitative information of internal bioluminescent sources are then reviewed. The latest application examples of BLT in tumor study and drug discovery are introduced and compared with other mature imaging technologies. Finally, the paper is concluded and an attractive prospect for BLT is predicted.

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