Article

Far-ultraviolet laser ablation of atherosclerotic lesions

  1. Ralph Linsker Md, Phd1,*,
  2. R. Srinivasan PhD1,
  3. James J. Wynne PhD1,
  4. Daniel R. Alonso MD2

Article first published online: 12 DEC 2005

DOI: 10.1002/lsm.1900040212

Issue

Lasers in Surgery and Medicine

Lasers in Surgery and Medicine

Volume 4, Issue 2, pages 201–206, 1984

Additional Information

How to Cite

Linsker, R., Srinivasan, R., Wynne, J. J. and Alonso, D. R. (1984), Far-ultraviolet laser ablation of atherosclerotic lesions. Lasers Surg. Med., 4: 201–206. doi: 10.1002/lsm.1900040212

Author Information

  1. 1

    IBM T.J. Watson Research Center, Yorktown Heights, NY

  2. 2

    Department of Pathology, Cornell University Medical College, New York, NY

*24–114, IBM T.J. Watson Research Center, P.O. Box 218, Yorktown Heights, NY 10598

Publication History

  1. Issue published online: 12 DEC 2005
  2. Article first published online: 12 DEC 2005
  3. Manuscript Accepted: 5 APR 1984

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Keywords:

  • atherosclerosis;
  • far-ultraviolet laser;
  • ablative photodecomposition;
  • catheterization;
  • excimer laser

Abstract

Far-ultraviolet (far-UV) (193 nm) laser radiation ablates arterial wall tissue, including noncalcified atherosclerotic lesions, with no apparent thermal damage to remaining tissue. This effect contrasts sharply with the thermal damage produced by visible-wavelength laser irradiation. The mechanism by which far-UV radiation interacts with tissue is predominantly photochemical rather than photothermal. Potential clinical applications include thsoe in which geometrically precise removal of tissue, without thermal damage to the reamaining substrate, is desired. Ultraviolet laser catheterization appears practical with respect to the availability of fiberoptic materials and high-pulse-rate excimer lasers.

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