Article

He-Ne laser effects on blood microcirculation during wound healing: A method of in vivo study through laser Doppler flowmetry

  1. Silvia Cristina Núñez MSc1,*,
  2. Gessé E.C. Nogueira PhD1,
  3. Martha S. Ribeiro PhD1,
  4. Aguinaldo S. Garcez MSc1,
  5. José L. Lage-Marques PhD2

Article first published online: 20 DEC 2004

DOI: 10.1002/lsm.20109

Issue

Lasers in Surgery and Medicine

Lasers in Surgery and Medicine

Volume 35, Issue 5, pages 363–368, December 2004

Additional Information

How to Cite

Núñez, S. C., Nogueira, G. E.C., Ribeiro, M. S., Garcez, A. S. and Lage-Marques, J. L. (2004), He-Ne laser effects on blood microcirculation during wound healing: A method of in vivo study through laser Doppler flowmetry. Lasers Surg. Med., 35: 363–368. doi: 10.1002/lsm.20109

Author Information

  1. 1

    Centro de Lasers e aplicac̃oes—Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, São Paulo, Brazil 05508-000

  2. 2

    School of Dentistry, University of São Paulo, SP, Brazil 05508-000

*Av. Lineu Prestes, 2242, Cidade Universitária, São Paulo, SP, Brazil 05508-000.

Publication History

  1. Issue published online: 20 DEC 2004
  2. Article first published online: 20 DEC 2004
  3. Manuscript Accepted: 8 SEP 2004

Funded by

  • FAPESP (Fundação de Amparo a Pesquisa do Estado de São Paulo), SP, Brazil

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Keywords:

  • biomodulation;
  • blood flow;
  • laser Doppler;
  • low-intensity laser therapy;
  • skin repair

Abstract

Background and Objectives

Low-intensity laser therapy (LILT) is widely used for wound healing promotion and its mechanism of action may be due to an enhancement of blood supply. The aim of this study was to evaluate blood flow alterations in a wound healing model, using laser Doppler flowmetry (LDF) associated with a normalized perfusion parameter.

Study Design/Materials and Methods

An injury was provoked in 15 rats and blood flow was measured periodically over a period of 21 days. Control groups were established to evaluate LDF and He-Ne laser effects on microcirculation. A 1 J/cm2 dose was utilized, with 6 mW/cm2 irradiance.

Results

The results demonstrated flow alterations provoked by lesion, and inflammatory response (P < 0.05). There were no statistical differences between groups.

Conclusions

The results did not show a significant sustained effect on microcirculation with this He-Ne dose. Lasers Surg. Med. 35:363–368, 2004. © 2004 Wiley-Liss, Inc.

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