Photodynamic therapy of head and neck basal cell carcinoma according to different clinicopathologic features
Article first published online: 17 JUN 2005
Copyright © 2005 Wiley-Liss, Inc.
Lasers in Surgery and Medicine
Volume 36, Issue 5, pages 377–382, June 2005
How to Cite
Kaviani, A., Ataie-Fashtami, L., Fateh, M., Sheikhbahaee, N., Ghodsi, M., Zand, N. and Djavid, G. E. (2005), Photodynamic therapy of head and neck basal cell carcinoma according to different clinicopathologic features. Lasers Surg. Med., 36: 377–382. doi: 10.1002/lsm.20186
- Issue published online: 17 JUN 2005
- Article first published online: 17 JUN 2005
- Manuscript Accepted: 24 MAR 2005
- National Research Center for Medical Science (NRCMS) of I R Iran
- basal cell carcinoma;
- photodynamic therapy;
- systemic photosensitizer
Background and Objectives
We aimed to treat different pathologic types of basal cell carcinomas (BCCs) using photodynamic therapy (PDT).
Study Design/Materials and Methods
Thirty lesions in six patients underwent PDT. The photosensitizer used was Photoheme, a hematoporphyrin derivative IX. It was injected intravenously at the dose of 2–3.25 mg/kg. After 24 hours, the lesions were illuminated by laser light (λ = 632 nm, light exposure dose = 100–200 J/cm2). Lesions were evaluated pre and post-operatively and at follow-up sessions (of up to 6 months).
After a single session of PDT, the average response rate in different histopathologic kinds of basal cell carcinoma (e.g., ulcerative, superficial, nodular, and pigmented forms) were 100%, 62%, 90%, and 14%, respectively. In patients who responded completely, the cosmetic results were excellent and there were no recurrence at 6th month of follow-up.
Although PDT seems to be an effective treatment modality for superficial, ulcerative, and nodular BCCs, it is not recommended for pigmented lesions. Lasers Surg. Med. 36:377–382, 2005. © 2005 Wiley-Liss, Inc.