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Keywords:

  • epidermal growth factor receptor (EGFR);
  • gold nanoshells;
  • hypericin;
  • photodynamic therapy (PDT);
  • photothermal therapy (PTT)

Abstract

Background and Objective

Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment.

Study Design/Materials and Methods

We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm2 and compare their cell viability using crystal fast violet assay.

Results

Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%.

Conclusion

A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment. Lesers Surg. Med. 40:584–589, 2008. © 2008 Wiley-Liss, Inc.