Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Article first published online: 12 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Lasers in Surgery and Medicine
Volume 44, Issue 6, pages 482–489, August 2012
How to Cite
Duong, S., Youssef, J., Pimenta, P., Aguigam, H., Zhang, J., Calantog, A., Pilch, S., Masters, J. G. and Wilder-Smith, P. (2012), An imaging-based approach to the evaluation of xerostomia. Lasers Surg. Med., 44: 482–489. doi: 10.1002/lsm.22039
Author's contribution: S.D. and J.Y.: imaging, data extraction; P.P.: study design, data interpretation, manuscript preparation; H.A., A.C.: imaging, data extraction, manuscript preparation; J.Z.: imaging, data extraction, and interpretation; S.P. and J.G.M.: study design, data interpretation and analysis, manuscript preparation; P.W.S.: study design and oversight, imaging, clinical examinations, data interpretation, manuscript preparation.
- Issue published online: 12 JUL 2012
- Article first published online: 12 JUN 2012
- Manuscript Accepted: 9 MAY 2012
- NIH. Grant Numbers: 5P41RR001192-32, K25HL-102055
- The Tobacco-Related Disease Research Program. Grant Number: 19KT-0034
- Colgate Palmolive Company
- dry mouth intervention;
- optical coherence tomography
Background and Objective
Goal was to evaluate the potential of in vivo optical coherence tomography (OCT) imaging to determine the response of patients with xerostomia to a dry mouth toothpaste versus fluoride toothpaste placebo.
Study Design/Materials and Methods
Ten subjects with xerostomia participated in this double-blind, crossover, placebo-controlled study. After examination and OCT imaging, subjects used the first product for 15 days, followed by a 7-day washout period, and then they used the second product for 15 days. Data were acquired at 5-day intervals, also before and after the washout.
Visual examination and tongue blade adhesion test did not reflect response to the product. Two imaging-based markers were identified: (i) In OCT images, epithelial thickness increased significantly (P < 0.05) after use of the dry mouth toothpaste, but did not change significantly (P > 0.05) after the use of a fluoride toothpaste and (2) Optical backscattering data showed progressive characteristic changes from baseline with use of the active product.
In this pilot study using in vivo OCT imaging, it was possible to detect and measure oral epithelial response to the dry mouth product versus placebo in patients with xerostomia.
This approach may permit site-specific assessment of xerostomia, individualized treatment planning and monitoring, and sequential mucosal mapping in patients with dry mouth. Lasers Surg. Med. 44: 482–489, 2012. © Wiley Periodicals, Inc.