Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Michael R. Hamblin is on the scientific advisory board and holds stock in Transdermal Cap Inc. He has been on the scientific advisory board and has received sponsored research funding from Lexington Int. He has been an expert witness for Advanced Hair Studio Australia. Other authors reported no conflict of interest.
Low-level laser (light) therapy (LLLT) for treatment of hair loss
Article first published online: 23 AUG 2013
© 2013 Wiley Periodicals, Inc.
Lasers in Surgery and Medicine
Volume 46, Issue 2, pages 144–151, February 2014
How to Cite
Avci, P., Gupta, G. K., Clark, J., Wikonkal, N. and Hamblin, M. R. (2014), Low-level laser (light) therapy (LLLT) for treatment of hair loss. Lasers Surg. Med., 46: 144–151. doi: 10.1002/lsm.22170
- Issue published online: 18 FEB 2014
- Article first published online: 23 AUG 2013
- Manuscript Accepted: 30 JUL 2013
- US NIH. Grant Number: R01AI050875
- androgenetic alopecia;
- hair loss;
- low level laser (light)
Alopecia is a common disorder affecting more than half of the population worldwide. Androgenetic alopecia, the most common type, affects 50% of males over the age of 40 and 75% of females over 65. Only two drugs have been approved so far (minoxidil and finasteride) and hair transplant is the other treatment alternative. This review surveys the evidence for low-level laser therapy (LLLT) applied to the scalp as a treatment for hair loss and discusses possible mechanisms of actions.
Methods and Materials
Searches of PubMed and Google Scholar were carried out using keywords alopecia, hair loss, LLLT, photobiomodulation.
Studies have shown that LLLT stimulated hair growth in mice subjected to chemotherapy-induced alopecia and also in alopecia areata. Controlled clinical trials demonstrated that LLLT stimulated hair growth in both men and women. Among various mechanisms, the main mechanism is hypothesized to be stimulation of epidermal stem cells in the hair follicle bulge and shifting the follicles into anagen phase.
LLLT for hair growth in both men and women appears to be both safe and effective. The optimum wavelength, coherence and dosimetric parameters remain to be determined. Lasers Surg. Med. 46:144–151, 2014. © 2013 Wiley Periodicals, Inc.