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Liver transplantation for hepatocellular carcinoma: The MELD impact

  1. Pratima Sharma1,
  2. Vijayan Balan1,†,*,
  3. Jose L. Hernandez3,
  4. Ann M. Harper4,
  5. Erick B. Edwards4,
  6. Hector Rodriguez-Luna1,
  7. Thomas Byrne1,
  8. Hugo E. Vargas1,
  9. David Mulligan2,
  10. Jorge Rakela1,
  11. Russell H. Wiesner5

Article first published online: 6 JAN 2004

DOI: 10.1002/lt.20012

Issue

Liver Transplantation

Liver Transplantation

Volume 10, Issue 1, pages 36–41, January 2004

Additional Information

How to Cite

Sharma, P., Balan, V., Hernandez, J. L., Harper, A. M., Edwards, E. B., Rodriguez-Luna, H., Byrne, T., Vargas, H. E., Mulligan, D., Rakela, J. and Wiesner, R. H. (2004), Liver transplantation for hepatocellular carcinoma: The MELD impact. Liver Transpl, 10: 36–41. doi: 10.1002/lt.20012

Author Information

  1. 1

    Transplantation Medicine, Mayo Clinic, Scottsdale, AZ

  2. 2

    Transplantation Surgery, Mayo Clinic, Scottsdale, AZ

  3. 3

    Section of Biostatistics, Mayo Clinic, Scottsdale, AZ

  4. 4

    United Network of Organ Sharing, Richmond, VA

  5. 5

    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN

  1. †

    Telephone: 480-342-0516; FAX: 480-324-2324

*Division of Transplantation Medicine, Mayo Clinic Hospital, 5777 E. Mayo Blvd., 5th Fl., Phoenix, AZ 85054

  1. †

    Telephone: 480-342-0516; FAX: 480-324-2324

Publication History

  1. Issue published online: 6 JAN 2004
  2. Article first published online: 6 JAN 2004

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References

  • 1
    El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999; 340: 745–750.
  • 2
    Okuda K. Hepatocellular carcinoma: recent progress. Hepatology 1992; 15: 948–963.
    Direct Link:
  • 3
    El-Serag HB. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 2002; 36( suppl 1): S74–83.
    Direct Link:
  • 4
    Rakela J, Vargas HE. Hepatitis C: magnitude of the problem. Liver Transpl 2002; 8( suppl 1): S3–6.
    Direct Link:
  • 5
    Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, et al. A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 candidates with viral and alcoholic cirrhosis. Hepatology 1993; 18: 47–53.
    Direct Link:
  • 6
    Barbara L, Benzi G, Gaiani S, Fusconi F, Zironi G, Siringo S, et al. Natural history of mall untreated hepatocellular carcinoma in cirrhosis: a multivariate analysis of prognostic factors of tumor growth rate and patient survival. Hepatology 1992; 16: 132–137.
    Direct Link:
  • 7
    Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693–699.
  • 8
    Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in candidates with end-stage liver disease. Hepatology 2001; 33: 464–470.
    Direct Link:
  • 9
    McCaughan GW, Strasser SI. To MELD or not to MELD [letter to the editor]? Hepatology 2001; 34: 215–216.
    Direct Link:
  • 10
    Wiesner RH, McDiarmid SV, Kamath PS, Edwards EB, Malinchoc M, Kremers WK, et al. MELD and PELD: application of survival models to liver allocation. Liver Transpl 2001; 7: 567–580.
    Direct Link:
  • 11
    Pagliaro L. MELD: the end of Child-Pugh classification? J Hepatol 2002; 36: 141–142.
  • 12
    Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in candidates undergoing transjugular intrahepatic portosystemic shunts. Hepatology 2000; 31: 864–871.
    Direct Link:
  • 13
    Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P, Kremers W, Lake J, Howard T, Merion R, Wolfe R, Krom R, and the United network for organ sharing liver disease severity score committee. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003; 124: 91–96.
  • 14
    Freeman RB Jr, Wiesner RH, Harper A, McDiarmid SV, Lake J, Edwards E, et al. The new liver allocation system: moving toward evidence-based transplantation policy. Liver Transpl 2002; 8: 851–858.
    Direct Link:
  • 15
    OPTN/UNOS Liver and Intestinal Organ Transplantation Committee Meeting. Modifications to the policy 3.6.4.4 (liver candidates with hepatocellular carcinoma [HCC]). Available at: http://www.optn.org/policiesandbylaws/pdfs/policy_8.pdf. Accessed November 27, 2002.
  • 16
    Klintmalm GB. Liver transplantation for hepatocellular carcinoma: a registry report of the impact of tumor characteristics on outcome. Ann Surg 1998; 228: 479–490.
  • 17
    Yamamoto J, Iwatsuki S, Kosuge T, Dvorchik I, Shimada K, Marsh JW, et al. Should hepatomas be treated with hepatic resection or transplantation? Cancer 1999; 86: 1151–1158.
    Direct Link:
  • 18
    Otto G, Heuschen U, Hofmann WJ, Krumm G, Hinz U, Herfarth C. Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis. Ann Surg 1998; 227: 424–432.
  • 19
    Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic candidates. Ann Surg 1993; 218: 145–151.
  • 20
    Lucey MR, Brown KA, Everson GT, Fung JJ, Gish R, Keeffe EB, et al. Minimal criteria for placement of adults on the liver transplant waiting list: a report of a national conference organized by the American Society of Transplant Physicians and the American Association for the Study of Liver Diseases. Liver Transpl Surg 1997; 3: 628–637.
    Direct Link:
  • 21
    Wiesner RH, Freeman R, Edwards E, Merion R, Harper A. The MELD/PELD liver allocation policy is associated with a reduction in waiting list mortality while maintaining excellent post transplant patient and graft survival [abstract]. Gastroenterology 2003; 124 ( suppl 1): A708.
  • 22
    UNOS News Bureau. Liver policy outcomes encouraging at six months: some adjustments recommended. Available at: http://www.unos.org/news/. Accessed January 30, 2003.
  • 23
    OPTN/UNOS Liver and Intestinal Organ Transplantation Committee Meeting. Modifications to the policy 3.6.4.4 (amendment to the policy for liver candidates with hepatocellular carcinoma [HCC]). Available at: http://www.optn.org/ policiesandbylaws/pdfs/policy_8.pdf. Accessed May 27, 2003.
  • 24
    Freeman PB, Harper A, Edwards E, Wiesner R, Teperman L, Merion R, Wolfe R. The MELD/PELD system and hepatocellular cancer (HCC) [abstract]. Am J Transplant 2003 ( suppl 5): 284.
  • 25
    Freeman RB, Harper A, Edwards E, Wiesner R, Merion R, Wolfe R, Results of the first six months of liver allocation under the MELD/PELD system: Fewer waitlist deaths and more cadaveric transplant [abstract]. Am J Transplant 2003 ( suppl 5) 284.
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