Pringle's maneuver and selective inflow occlusion in living donor liver hepatectomy

Authors

  • Hiroshi Imamura,

    Corresponding author
    1. Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    • Hiroshi Imamura, MD, Division of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8600, Japan
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    • Telephone: 81-3-3815-5411, ext. 33321; FAX: 81-3-5800-8847

  • Norihiko Kokudo,

    1. Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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  • Yasuhiko Sugawara,

    1. Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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  • Keiji Sano,

    1. Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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  • Jun-ichi Kaneko,

    1. Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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  • Tadatoshi Takayama,

    1. Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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  • Masatoshi Makuuchi

    1. Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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Abstract

While inflow occlusion techniques such as Pringle's maneuver are accepted methods of reducing bleeding without inducing liver injury during liver surgery, donor hepatectomy for living donor liver transplantation is currently performed without inflow occlusion for fear that injury to the graft may result. We have performed donor hepatectomy for 12 years using selective intermittent inflow occlusion, a technique in which the portion used to form the graft is perfused during hepatectomy. Starting in November 2000, we applied intermittent Pringle's maneuver to donor hepatectomy in 81 cases of living donor liver transplantation. We reviewed our experience with Pringle's maneuver and selective inflow occlusion techniques in donor hepatectomy in living donor liver transplantation. The quality of the grafts was assessed and compared by determining maximum postoperative aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values. Neither primary nonfunction nor dysfunction occurred. Maximum AST values in the recipients were the same whether the liver segments that formed the grafts were totally ischemic during dissection (total ischemia), partially ischemic (partial ischemia), perfused only with arterial blood flow (portal ischemia), or not ischemic at all (no ischemia). Maximum ALT values in the recipients of the total ischemia group was lower, albeit not significantly, than in other groups. Total inflow occlusion can be applied to living donor hepatectomy without causing graft injury. In conclusion, because the transection surface is blood-free, there is decreased risk to the donor during living donor liver transplantation surgery, and surgeons should not hesitate to apply this technique because it contributes to donor safety. (Liver Transpl 2004;10:771–778.)

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