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Immunosuppression in liver transplantation
Article first published online: 19 OCT 2005
DOI: 10.1002/lt.20614
Copyright © 2005 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Post, D. J., Douglas, D. D. and Mulligan, D. C. (2005), Immunosuppression in liver transplantation. Liver Transpl, 11: 1307–1314. doi: 10.1002/lt.20614
Publication History
- Issue published online: 19 OCT 2005
- Article first published online: 19 OCT 2005
- Manuscript Accepted: 29 AUG 2005
- Manuscript Received: 1 AUG 2005
References
- 1. The future of organ transplantation—From the Laboratory to the Clinic. In: World Congress on Medicine and Health; 2000; Hannover Conference Center; Hannover, Germany: July 21–August 31, 2000.
- 2
- 3, , , , , , . Fifteen years of clinical liver transplantation. Gastroenterology 1979; 77: 375–388.
- 4, , . Liver transplantation: Where it's been and where it's going. Gastroenterol Clin North Am 1988; 17: 1–18.
- 5, , , , , , et al. Evolution of liver transplantation. Hepatology 1982; 2: 614–636.Direct Link:
- 6, . Orthotopic liver transplantation: The first 60 patients. Br Med J 1977; 1: 471–476.
- 7Novartis. History of Sandimmune. Available at http://www.novartis-transplant.com/history/history_sandimmune.jsp. Accessed September 23, 2005.
- 8, . Cyclosporin. A review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral). Drugs 1995; 50: 924–941.
- 9, , , , , , . End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: Risk of development and treatment. Transplantation 2001; 72: 1934–1939.
- 10, , , , . Update on liver transplantation using cyclosporine. Transplant Proc 2004; 36: 2525–2531.
- 11, , , , , . Randomized trial of cyclosporine microemulsion (neoral) versus conventional cyclosporine in liver transplantation: MILTON study. Multicentre International Study in Liver Transplantation of Neoral. Transplantation 1998; 66: 1632–1640.
- 12, , , , , , . A microemulsion of cyclosporine without intravenous cyclosporine in liver transplantation. Transplantation 1996; 62: 1798–1802.
- 13, . C2 monitoring of cyclosporine in de novo liver transplant recipients: the clinician;s perspective. Liver Transpl 2004; 10: 577–583.Direct Link:
- 14. History of FK506 Devolpment. In: RossiL, ed. Pittsburgh, PA: University of Pittsburgh Medical Center, 1991: 1–4.
- 15
- 16. A long-term comparison of tacrolimus (FK506) versus cyclosporine in liver transplantation: A report of the United States FK506 Study Group. Transplantation 1998; 66: 493–499.
- 17OPTN/SRTR. Immunosuppression: Evolution in practice and trends, 1993-2003. In: MillerSN, FinleyMP, LiS, eds. Annual Report 2004. Ann Arbor, MI: OPTN/SRTR, 2004.
- 18. Immunosuppressive medications and protocols. In: DanovitchGM, ed. Handbook of Kidney Transplantation. Philadelphia, PA: Lippincott Williams & Wilkins, 2001: 82–83.
- 19, , , , , . Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation. Ther Drug Monit 1999; 21: 35–43.
- 20, , , , . Immunosuppression in liver transplantation:Beyond calcineurin inhibitors. Liver Transpl 2005; 11: 267–280.Direct Link:
- 21, , , , , . A randomized clinical trial of prophylactic OKT3 monoclonal antibody in liver allograft recipients. Arch Surg 1990; 125: 781–784;discussion 785.
- 22, , , , . Rejection in liver transplantation. Hepatology 1989; 10: 978–985.Direct Link:
- 23. Tacrolimus rescue in liver transplant patients with refractory rejection or intolerance or malabsorption of cyclosporine. The US Multicenter FK506 Liver Study Group. Liver Transpl Surg 1999; 5: 502–508.Direct Link:
- 24, , , , , , et al. Improved treatment response with basiliximab immunoprophylaxis after liver transplantation: results from a double-blind randomized placebo-controlled trial. Liver Transpl 2002; 8: 132–142.Direct Link:
- 25. Sirolimus: Its discovery, biological properties, and mechanism of action. Transplant Proc 2003; 35(Suppl): 7S–14S.
- 26, , , , , , et al. Orthotopic liver transplantation using low dose tacrolimus and sirolimus. Liver Transpl 2001; 7: 701–708.Direct Link:
- 27, , , , , . Sirolimus-tacrolimus combination immunosuppression. Lancet 2000; 355: 376–377.
- 28, , , , . Steroid-free liver transplantation using rabbit antithymocyte globulin induction: Results of a prospective randomized trial. Liver Transpl 2001; 7: 693–697.Direct Link:
- 29, , , , , , et al. Corticosteroid-free immunosuppression with tacrolimus following induction with daclizumab: A large randomized clinical study. Liver Transpl 2005; 11: 61–67.Direct Link:
- 30, , , , , , et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 2003; 349: 931–940.
- 31, , . Mycophenolate mofetil for renal dysfunction in liver transplant recipients on cyclosporine or tacrolimus: Randomized, prospective, multicenter pilot study results. Transplantation 2005; 80: 18–25.
- 32, , , , , , et al. Replacement of calcineurin inhibitors with mycophenolate mofetil in liver-transplant patients with renal dysfunction: A randomised controlled study. Lancet 2001; 357: 587–591.
- 33, , , , . Predictors of improvement in renal function after calcineurin inhibitor withdrawal for post-liver transplant renal dysfunction. Clin Transplant 2005; 19: 193–198.Direct Link:
- 34, , , , , , . The efficacy and limitations of sirolimus conversion in liver transplant patients who develop renal dysfunction on calcineurin inhibitors. Dig Dis Sci 2004; 49: 1029–1035.
- 35, , , , , . Immunosuppression: Evolution in practice and trends, 1993-2003. Am J Transplant 2005; 5: 874–886.Direct Link:
- 36, , , . Immunological monitoring as a guide to the management of transplant recipients. Surg Clin North Am 1979; 59: 253–281.

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