The first 3 authors contributed equally to this article.
Sexual health after orthotopic liver transplantation†
Article first published online: 1 JUN 2006
Copyright © 2006 American Association for the Study of Liver Diseases
Volume 12, Issue 10, pages 1478–1484, October 2006
How to Cite
Ho, J. K., Ko, H. H., Schaeffer, D. F., Erb, S. R., Wong, C., Buczkowski, A. K., Scudamore, C. H. and Yoshida, E. M. (2006), Sexual health after orthotopic liver transplantation. Liver Transpl, 12: 1478–1484. doi: 10.1002/lt.20831
This work was presented in part as a poster at the World Congress of Gastroenterology in Montreal, Canada, in September 2005.
- Issue published online: 26 SEP 2006
- Article first published online: 1 JUN 2006
- Manuscript Accepted: 10 APR 2006
- Manuscript Received: 2 FEB 2006
- Pfizer-Canada Inc.
Many studies have reported improved health-related quality of life outcomes after orthotopic liver transplantation; however, specific research regarding sexual health in liver transplant recipients is limited. We surveyed liver transplant recipients to determine the prevalence of sexual dysfunction. Of the 320 adult liver transplant recipients surveyed by mailed questionnaire, 150 responded (42%). The median age was 54 years. A total of 62% of respondents were male, and 93% were at least 1 year after transplantation. Thirty-six respondents (24%) reported sexual dysfunction before transplantation; this persisted in 22 patients (15%) after transplantation. A total of 48 respondents (32%) reported de novo sexual dysfunction after transplantation. After transplantation, 23% of male and 26% of female respondents reported decreased libido, and 33% of men and 26% of women reported having difficulty reaching orgasm with intercourse. A total of 42% of respondents felt that immunosuppressive medication was the main contributing factor to their sexual problems: 33% and 35% of respondents receiving tacrolimus or cyclosporine monotherapy, respectively, experienced some degree of sexual problems after transplantation. Despite the reported sexual problems, 59% of respondents were “moderately” to “very satisfied” with their sexual relationships after transplantation. Nineteen percent of the respondents used sildenafil to improve their sexual function, and 65% of these reported benefit. In conclusion, sexual problem after orthotopic liver transplantation is a common but poorly studied problem. Although this single-center study has shed some light on the relationship between liver transplantation and sexual health, further prospective studies, involving larger study population and validated instruments, will be needed to better evaluate the influence of liver transplantation on recipients' sexual health. Liver Transpl 12:1478-1484, 2006. © 2006 AASLD.