• 1
    Mor E, Jennings L, Gonwa TA, Holman MJ, Gibbs J, Solomon H, et al. The impact of operative bleeding on outcome in transplantation of the liver. Surg Gynecol Obstet 1993; 176: 219227.
  • 2
    Ramos E, Dalmau A, Sabate A, Lama C, Llado L, Figueras J, et al. Intraoperative red blood cell transfusion in liver transplantation: Influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl 2003; 9: 13201327.
  • 3
    Cacciarelli TV, Keeffe EB, Moore DH, Burns W, Chuljian P, Busque S, et al. Primary liver transplantation without transfusion of red blood cells. Surgery 1996; 120: 698704.
  • 4
    Porte RJ. Antifibrinolytics in liver transplantation: They are effective, but what about the risk-benefit ratio? Liver Transpl 2004; 10: 285288.
  • 5
    Dalmau A, Sabate A, Koo M, Bartolome C, Rafecas A, Figueras J, et al. The prophylactic use of tranexamic acid and aprotinin in orthotopic liver transplantation: A comparative study. Liver Transpl 2004; 10: 279284.
  • 6
    Dalmau A, Sabate A, Acosta F, Garcia-Huete L, Koo M, Sansano T, et al. Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation. Anesth Analg 2000; 91: 2934.
  • 7
    Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999; 88: 312319.
  • 8
    Massicotte L, Sassine MP, Lenis S, Seal RF, Roy A. Survival rate changes with transfusion of blood products during liver transplantation. Can J Anaesth 2005; 52: 148155.
  • 9
    Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464470.
  • 10
    Devlin TF, Weeks BJ. Spline functions for logistic regression modeling. Annual SAS Users Group International Conference. Cary, NC: SAS Institute; 1986: 646651.
  • 11
    Harrell FE. SAS macros and data step programs useful in survival analysis and logictic regression. Accessed July 1, 2006.
  • 12
    Katz MH. Multivariable Analysis: A Practical Guide for Clinicians. Cambridge, Mass: Cambridge University Press; 1999.
  • 13
    FeinsteinAR, FeinsteinAR, ed. Multiple Logistic Regression, Multivariable Analysis: An Introduction. New Haven, Conn: Yale University Press; 1996.
  • 14
    LezzoniLI, ed. Evaluating the Performance of Risk Adjustment Methods: Dichotomous Outocmes. Risk Adjustment for Measuring Healthcare Outcomes. 2nd ed. Chicago, Ill: Health Aministration Press; 1997.
  • 15
    Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Polanczyk CA, Cook EF, et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation 1999; 100: 10431049.
  • 16
    Findlay JY, Rettke SR. Poor prediction of blood transfusion requirements in adult liver transplantations from preoperative variables. J Clin Anesth 2000; 12: 319323.
  • 17
    Hendriks HG, van der MJ, Klompmaker IJ, Choudhury N, Hagenaars JA, Porte RJ, et al. Blood loss in orthotopic liver transplantation: A retrospective analysis of transfusion requirements and the effects of autotransfusion of cell saver blood in 164 consecutive patients. Blood Coagul Fibrinolysis 2000; 11(Suppl 1): S87S93.
  • 18
    Steib A, Freys G, Lehmann C, Meyer C, Mahoudeau G. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can J Anaesth 2001; 48: 10751079.
  • 19
    Massicotte L, Sassine MP, Lenis S, Roy A. Transfusion predictors in liver transplant. Anesth Analg 2004; 98: 12451251.
  • 20
    Karkouti K, Wijeysundera DN, Yau TM, Beattie WS, Abdelnaem E, McCluskey SA, et al. The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 2004; 44: 14531462.
  • 21
    Cacciarelli TV, Keeffe EB, Moore DH, Burns W, Busque S, Concepcion W, et al. Effect of intraoperative blood transfusion on patient outcome in hepatic transplantation. Arch Surg 1999; 134: 2529.
  • 22
    Porte RJ, Molenaar IQ, Begliomini B, Groenland TH, Januszkiewicz A, Lindgren L, et al. Aprotinin and transfusion requirements in orthotopic liver transplantation: A multicentre randomised double-blind study. EMSALT Study Group. Lancet 2000; 355: 13031309.
  • 23
    Karkouti K, Beattie WS, Wijeysundera DN, Yau TM, McCluskey SA, Ghannam M, et al. Recombinant factor VIIa for intractable blood loss after cardiac surgery: A propensity score-matched case-control analysis. Transfusion 2005; 45: 2634.
  • 24
    Mayer SA, Brun NC, Begtrup K, Davis SM, Diringer MN, Skolnick BE, et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 2005; 352: 777785.
  • 25
    Planinsic RM, van der MJ, Testa G, Grande L, Candela A, Porte RJ, et al. Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease. Liver Transpl 2005; 11: 895900.
  • 26
    Lodge JP, Jonas S, Jones RM, Olausson M, Mir-Pallardo J, Soefelt S, et al, for the rFVIIa OLT Study Group. Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation. Liver Transpl 2005; 11: 973979.