Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

Authors

  • Vishal Bhagat,

    1. Center for Liver Diseases, Division of Hepatology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL
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  • Julie A. Foont,

    1. Center for Liver Diseases, Division of Hepatology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL
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  • Eugene R. Schiff,

    1. Center for Liver Diseases, Division of Hepatology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL
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  • Arie Regev

    Corresponding author
    1. Center for Liver Diseases, Division of Hepatology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL
    • Division of Hepatology, Leonard M. Miller School of Medicine, University of Miami, 1500 Northwest 12th Avenue, Suite 1101, Miami, FL 33136
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    • Telephone: 305-243-5787; FAX: 305-243-3877


Abstract

Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV–coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear. Liver Transpl 14:92–95, 2008. © 2007 AASLD.

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