Pregnancy and cirrhosis

Authors

  • Jennifer Tan,

    1. Department of Medicine, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, CA
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  • Bijal Surti,

    1. Department of Medicine, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, CA
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  • Sammy Saab

    Corresponding author
    1. Department of Medicine, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, CA
    2. Department of Surgery, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, CA
    • Pfleger Liver Institute, UCLA Medical Center, 200 Medical Plaza, Suite 214, Los Angeles, CA 90095
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    • Telephone: 310-206-6705; FAX: 310-206-4197


Abstract

As the treatment of cirrhosis improves, pregnancy in patients with cirrhosis is likely to become more common. Although maternal and fetal mortality is expected to similarly improve, pregnant patients with cirrhosis face unique risks. These include higher rates of spontaneous abortion and prematurity and a potential for life-threatening variceal hemorrhage, hepatic decompensation, splenic artery aneurysm rupture, and postpartum hemorrhage. Pregnancy outcome may be influenced by the underlying etiology of liver disease, as in viral and autoimmune hepatitis. Medications also impact the course of pregnancy, and must be tailored appropriately during this time. Liver Transpl 14:1081–1091, 2008. © 2008 AASLD.

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