Etiology and prognosis of acute liver failure in children

Authors

  • Anil Dhawan

    Corresponding author
    1. Paediatric Liver Centre, King's College London School of Medicine, King's College Hospital, London, United Kingdom
    • Paediatric Liver Centre, King's College London School of Medicine, King's College Hospital, London, United Kingdom SE 59RS
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    • Telephone: 0044 203 299 3578; FAX: 0044 203 299 4228


Abstract

Key Points

  • 1The etiology of acute liver failure in children differs from that in adults, with metabolic conditions being commoner in Europe and North America and hepatitis A being the commonest cause in Asia and South America.
  • 2Encephalopathy usually is a late feature and is not essential for the diagnosis.
  • 3Unlike adults, there are no good prognostic criteria that can predict survival without liver transplantation.
  • 4It is important to exclude genetic multisystem disorders before liver transplantation is considered.

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