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Hepatosplenic γδ T-cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature

  1. Philip R. Roelandt1,
  2. Johan Maertens2,
  3. Peter Vandenberghe3,
  4. Chris Verslype1,
  5. Tania Roskams4,
  6. Raymond Aerts5,
  7. Frederik Nevens1,
  8. Daan Dierickx2,†,*

Article first published online: 26 JUN 2009

DOI: 10.1002/lt.21748

Issue

Liver Transplantation

Liver Transplantation

Volume 15, Issue 7, pages 686–692, July 2009

Additional Information

How to Cite

Roelandt, P. R., Maertens, J., Vandenberghe, P., Verslype, C., Roskams, T., Aerts, R., Nevens, F. and Dierickx, D. (2009), Hepatosplenic γδ T-cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature. Liver Transplantation, 15: 686–692. doi: 10.1002/lt.21748

Author Information

  1. 1

    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium

  2. 2

    Department of Haematology, University Hospital Gasthuisberg, Leuven, Belgium

  3. 3

    Department of Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium

  4. 4

    Department of Anatomopathology, University Hospital Gasthuisberg, Leuven, Belgium

  5. 5

    Department of Abdominal Transplantation Surgery, University Hospital Gasthuisberg, Leuven, Belgium

  1. †

    Telephone: 0032 16/34.68.80; FAX: 0032 16/34.68.85

*UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium

Publication History

  1. Issue published online: 26 JUN 2009
  2. Article first published online: 26 JUN 2009
  3. Manuscript Accepted: 22 DEC 2008
  4. Manuscript Received: 11 SEP 2007

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Abstract

Hepatosplenic γδ T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer–like Vδ1-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic γδ-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed. Liver Transpl 15:686–692, 2009. © 2009 AASLD.

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