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Hepatosplenic γδ T-cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature
Article first published online: 26 JUN 2009
DOI: 10.1002/lt.21748
Copyright © 2009 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Roelandt, P. R., Maertens, J., Vandenberghe, P., Verslype, C., Roskams, T., Aerts, R., Nevens, F. and Dierickx, D. (2009), Hepatosplenic γδ T-cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature. Liver Transpl, 15: 686–692. doi: 10.1002/lt.21748
Publication History
- Issue published online: 26 JUN 2009
- Article first published online: 26 JUN 2009
- Manuscript Accepted: 22 DEC 2008
- Manuscript Received: 11 SEP 2007
REFERENCES
- 1, , , , , , et al. Posttransplant T-cell lymphoproliferative disorder—an aggressive, late complication of solid-organ transplantation. Blood 1996; 88: 3626–3633.
- 2, . Hepatosplenic T-cell lymphoma. In: JaffeES, HarrisNL, SteinH, VardimanJW, eds. World Health Organization Classification of Tumours: Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissue. Lyon, France: IARC Press; 2001: 210.
- 3. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 2000; 14: 991–997.
- 4, , , , , , et al. Hepatosplenic γδ T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood 2003; 102: 4261–4269.
- 5. Identifying the patient at risk for post-transplant lymphoproliferative disorder. Transpl Infect Dis 2001; 3: 70–78.Direct Link:
- 6. Post-transplant lymphoproliferative disorders. Oncologist 2006; 11: 674–680.
- 7, , , , , , et al. Posttransplantation lymphoproliferative disorders. Arch Intern Med 2003; 163: 1997–2004.
- 8, , , , , , et al. Posttransplant lymphoproliferative disorders in liver transplantation: a 20-year experience. Ann Surg 2002; 236: 429–436.
- 9, , , . Post-transplant lymphoproliferative disorders. In: JaffeES, HarrisNL, SteinH, VardimanJW, eds. World Health Organization Classification of Tumours: Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissue. Lyon, France: IARC Press; 2001: 264–269.
- 10, , , , , , et al. Prognostic analysis for survival in adult solid organ transplant recipients with post-transplantation lymphoproliferative disorders. J Clin Oncol 2005; 23: 7574–7582.
- 11, , , , , , et al. Role of hepatitis C virus in lymphoproliferative disorders after liver transplantation. Hepatology 1999; 30: 775–778.Direct Link:
- 12, , , , , , et al. Hepatitis C virus infection and risk of posttransplantation lymphoproliferative disorder among solid organ transplant recipients. Blood 2007; 110: 4599–4605.
- 13, . γδ T-cell lymphomas: a homogenous entity? Histopathology 2000; 36: 294–305.Direct Link:
- 14, , , , , , et al. Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic γδ T cell lymphoma. Leukemia 1997; 11: 1367–1372.
- 15, , , , , , et al. Hepatosplenic and subcutaneous panniculitis-like γ/δ T cell lymphomas are derived from different Vδ subsets of γ/δ T lymphocytes. J Mol Diagn 2000; 2: 11–19.
- 16, , , , , , et al. Hepatosplenic αβ T-cell lymphoma: an unusual case with clinical, histologic, and cytogenetic features of γδ hepatosplenic T-cell lymphoma. Am J Surg Pathol 2000; 24: 1027–1032.
- 17, , . Expansion of γδ T-cells in Behçet's disease: role of disease activity and microbial flora in oral ulcers. J Lab Clin Med 2003; 141: 33–40.
- 18, , . Emerging role of γδ T-cells in health and disease. Blood Rev 2002; 16: 203–206.
- 19, , , , , . γδ T-cell neoplasms: a clinicopathological study of 11 cases. Ann Oncol 2002; 13: 1792–1798.
- 20, , , , , , et al. High frequency of circulating γδ T cells with dominance of the Vδ1 subset in a healthy population. Int Immunol 2000; 12: 797–805.
- 21, , , , , , et al. Hepatosplenic γδ T-cell lymphoma: relation to Epstein-Barr virus and activated cytotoxic molecules. Histopathology 2000; 36: 127–135.Direct Link:
- 22, , , . Characterization of liver T-cell receptor γδ T cells obtained from individuals chronically infected with hepatitis C virus (HCV): evidence for these T cells playing a role in the liver pathology associated with HCV infections. Hepatology 2001; 33: 1312–1320.Direct Link:
- 23, , , . CD4- CD8- ‘double-negative’ cutaneous T-cell lymphomas share common histologic features and an aggressive clinical course. Am J Surg Pathol 2002; 26: 225–231.
- 24, , , , , , et al. Perforin-dependent killing of tumor cells by Vγ1Vδ1-bearing T-cells. Immunol Lett 2003; 86: 113–119.
- 25, , , . Cytotoxic T-lymphocyte differentiation and cytogenetic alterations in γδ hepatosplenic T-cell lymphoma and posttransplant lymphoproliferative disorders. Blood 1997; 89: 3490–3491.
- 26, , , , , , et al. Hepatosplenic αβ T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic γδ T-cell lymphomas. Am J Surg Pathol 2001; 25: 285–296.
- 27, , , , , , et al. Distribution of T cells bearing different forms of the T cell receptor γ/δ in normal and pathological human tissues. J Immunol 1989; 143: 2480–2488.
- 28, , , , , , et al. Cytotoxic hepatosplenic γδ T-cell lymphoma following acute myeloid leukemia bearing two distinct γ chains of the T-cell receptor. Biologic and clinical features. Haematologica 2000; 85: 1024–1031.
- 29
- 30, , , , , , et al. Case of hepatosplenic γδ T-cell lymphoma presenting with severe hypersplenism. Am J Hematol 1999; 60: 313–314.Direct Link:
- 31, , , , , , et al. Hepato-splenic γδ T-cell lymphoma: a rare entity mimicking the hemophagocytic syndrome. Am J Hematol 1999; 60: 61–65.Direct Link:
- 32, , , , , . Gamma/delta T-cell hepatosplenic lymphoma: review of the literature, diagnosis by flow cytometry and concomitant autoimmune hemolytic anemia. Ann Hematol 1997; 74: 139–142.
- 33, , , , , , et al. Unusual peripheral T cell lymphoma presenting as acute liver failure and reappearing in the liver allograft. Transplantation 2000; 70: 1802–1805.
- 34, , , , , , et al. Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic γδ T-cell origin. Blood 1996; 88: 4265–4274.
- 35, , , , , , et al. Natural killer-like T-cell lymphomas: aggressive lymphomas of T-large granular lymphocytes. Blood 1996; 87: 1474–1483.
- 36, . Effects of formaldehyde fixation on protein secondary structure: a calorimetric and infrared spectroscopic investigation. J Histochem Cytochem 1991; 39: 225–229.
- 37, , , , . Hepatosplenic γ/δ T-cell lymphoma with isochromosome 7q, translocation t(7;21), and tetrasomy 8 in a 9-year-old girl. J Pediatr Hematol Oncol 2002; 24: 154–157.
- 38, , , , , , et al. Fluorescence in situ hybridization study of chromosome 7 aberrations in hepatosplenic T-cell lymphoma: isochromosome 7q as a common abnormality accumulating in forms with features of cytologic progression. Genes Chromosomes Cancer 2002; 33: 243–251.Direct Link:
- 39, , , , , , et al. Allogeneic stem cell transplantation for hepatosplenic gammadelta T-cell lymphoma. Leuk Lymphoma 2007; 48: 630–632.
- 40, , , , , , et al. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and the Mayo Clinic Organized International Consensus Development Meeting. Transplantation 1999; 68: 1517–1525.
- 41, , , , , , et al. Humanized anti-CD20 monoclonal antibody (Rituximab) treatment for post-transplant lymphoproliferative disorder. Clin Transpl 2003; 17: 417–422.Direct Link:
- 42, , , , , , et al. Anti-CD20 monoclonal antibody treatment of Epstein-Barr virus-induced intrahepatic lymphoproliferative disorder following liver transplantation. Transpl Int 2003; 16: 197–201.Direct Link:

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