• 1
    Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR, et al. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006; 44: 10391046.
  • 2
    Lisman T, Leebeek FW, de Groot PG. Haemostatic abnormalities in patients with liver disease. J Hepatol 2002; 37: 280287.
  • 3
    Porte RJ. Coagulation and fibrinolysis in orthotopic liver-transplantation—current views and insights. Semin Thromb Hemost 1993; 19: 191196.
  • 4
    Owen CA, Rettke SR, Bowie EJW, Cole TL, Jensen CC, Wiesner RH, et al. Hemostatic evaluation of patients undergoing liver-transplantation. Mayo Clin Proc 1987; 62: 761772.
  • 5
    Lisman T, Bongers TN, Adelmeijer J, Janssen HLA, de Maat MPM, de Groot PG, et al. Elevated levels of von Willebrand factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology 2006; 44: 5361.
  • 6
    Northup PG, McMahon MM, Ruhl AP, Altschuler SE, Volk-Bednarz A, Caldwell SH, et al. Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism. Am J Gastroenterol 2006; 101: 15241528.
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  • 7
    Northup PG, Sundaram V, Fallon MB, Reddy KR, Balogun RA, Sanyal AJ, et al. Hypercoagulation and thrombophilia in liver disease. J Thromb Haemost 2008; 6: 29.
  • 8
    Lisman T, Leebeek FW. Hemostatic alterations in liver disease: a review on pathophysiology, clinical consequences, and treatment. Dig Surg 2007; 24: 250258.
  • 9
    Tripodi A, Mannucci PM. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. J Hepatol 2007; 46: 727733.
  • 10
    Laffi G, Marra F, Tarquini R, Abbate R. Coagulation defects in cirrhosis—old dogmas not yet ready for burial. J Thromb Haemost 2006; 4: 20682069.
  • 11
    Warnaar N, Lisman T, Porte RJ. The two tales of coagulation in liver transplantation. Curr Opin Organ Transplant 2008; 13: 298303.
  • 12
    Lisman T, Adelmeijer J, de Groot PG, Janssen HL, Leebeek FW. No evidence for an intrinsic platelet defect in patients with liver cirrhosis—studies under flow conditions. J Thromb Haemost 2006; 4: 20702072.
  • 13
    Tripodi A, Primignani M, Chantarangkul V, Clerici M, Dell'Era A, Fabris F, et al. Thrombin generation in patients with liver cirrhosis: the role of platelets. Hepatology 2006; 44: 440445.
  • 14
    Federici AB, Berkowitz SD, Lattuada A, Mannucci PM. Degradation of von Willebrand factor in patients with acquired clinical conditions in which there is heightened proteolysis. Blood 1993; 81: 720725.
  • 15
    Porte RJ, Bontempo FA, Knot EA, Lewis JH, Kang YG, Starzl TE. Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation. Transplantation 1989; 47: 978984.
  • 16
    Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien PA. Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. Gastroenterology 2000; 118: 183191.
  • 17
    Stricker RB, Wong D, Shiu DT, Reyes PT, Shuman MA. Activation of plasminogen by tissue plasminogen activator on normal and thrombasthenic platelets: effects on surface proteins and platelet aggregation. Blood 1986; 68: 275280.
  • 18
    de Boer MT, Molenaar IQ, Hendriks HG, Slooff MJ, Porte RJ. Minimizing blood loss in liver transplantation: progress through research and evolution of techniques. Dig Surg 2005; 22: 265275.
  • 19
    Weeterings C, Adelmeijer J, Myles T, de Groot PG, Lisman T. Glycoprotein Ibalpha-mediated platelet adhesion and aggregation to immobilized thrombin under conditions of flow. Arterioscler Thromb Vasc Biol 2006; 26: 670675.
  • 20
    Lane DA, Ireland H, Wolff S, Ranasinghe E, Dawes J. Detection of enhanced in vivo platelet alpha-granule release in different patient groups—comparison of beta-thromboglobulin, platelet factor 4 and thrombospondin assays. Thromb Haemost 1984; 52: 183187.
  • 21
    Rucinski B, Knight LC, Niewiarowski S. Clearance of human platelet factor 4 by liver and kidney: its alteration by heparin. Am J Physiol 1986; 251: H800H807.
  • 22
    Panasiuk A, Zak J, Panasiuk B, Prokopowicz D. Increase in expression of monocytic tissue factor (CD142) with monocytes and blood platelet activation in liver cirrhosis. Blood Coagul Fibrinolysis 2007; 18: 739744.
  • 23
    Ogasawara F, Fusegawa H, Haruki Y, Shiraishi K, Watanabe N, Matsuzaki S. Platelet activation in patients with alcoholic liver disease. Tokai J Exp Clin Med 2005; 30: 4148.
  • 24
    Panasiuk A, Prokopowicz D, Zak J, Matowicka-Karna J, Osada J, Wysocka J. Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4. Hepatogastroenterology 2001; 48: 818822.
  • 25
    Becker T, Jüttner B, Elsner HA, Meyer zu Vilsendorf A, Bornscheuer A, Nashan B, et al. Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection. Transpl Int 2004; 17: 442448.
  • 26
    Porte RJ, Blauw E, Knot EA, de Maat MP, de Ruiter C, Minke BC, et al. Role of the donor liver in the origin of platelet disorders and hyperfibrinolysis in liver transplantation. J Hepatol 1994; 21: 592600.
  • 27
    Massicotte L, Sassini MP, Lenis S, Seal RF, Roy A. Survival rate changes with transfusion of blood products during liver transplantation. Can J Anaesth 2005; 52: 148155.
  • 28
    de Boer MT, Christensen MC, Asmussen M, van der Hilst CS, Hendriks HGD, Slooff MJH, et al. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg 2008; 106: 3244.
  • 29
    Pereboom ITA, de Boer MT, Hendriks HGD, Haagsma EB, Lisman T, Porte RJ. Platelet transfusions during liver transplantation are associated with postoperative mortality due to acute lung injury. Anesth Analg. In press.
  • 30
    Pereboom IT, Adelmejer J, van Leeuwen Y, Hendriks HG, Porte RJ, Lisman T. Development of a severe von Willebrand factor/ADAMTS13 dysbalance during orthotopic liver transplantation. Am J Transplant 2009; 9: 11891196.