Perspectives in Liver Transplantation

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Infliximab treatment for steroid-refractory acute graft-versus-host disease after orthotopic liver transplantation: A case report

  1. Gaël Piton1,5,
  2. Fabrice Larosa2,5,
  3. Anne Minello6,
  4. Marie-Claude Becker1,5,
  5. Georges Mantion3,5,
  6. François Aubin4,5,
  7. Eric Deconinck2,5,
  8. Patrick Hillon6,
  9. Vincent Di Martino1,5,†,*

Article first published online: 26 JUN 2009

DOI: 10.1002/lt.21793

Issue

Liver Transplantation

Liver Transplantation

Volume 15, Issue 7, pages 682–685, July 2009

Additional Information

How to Cite

Piton, G., Larosa, F., Minello, A., Becker, M.-C., Mantion, G., Aubin, F., Deconinck, E., Hillon, P. and Di Martino, V. (2009), Infliximab treatment for steroid-refractory acute graft-versus-host disease after orthotopic liver transplantation: A case report. Liver Transplantation, 15: 682–685. doi: 10.1002/lt.21793

Author Information

  1. 1

    Service d'Hépatologie, Université de Franche Comté et Centre Hospitalier Universitaire de Besançon, Besançon, France

  2. 2

    Service d'Hématologie, Université de Franche Comté et Centre Hospitalier Universitaire de Besançon, Besançon, France

  3. 3

    Service de Chirurgie Digestive et Transplantation, Université de Franche Comté et Centre Hospitalier Universitaire de Besançon, Besançon, France

  4. 4

    Service de Dermatologie, Université de Franche Comté et Centre Hospitalier Universitaire de Besançon, Besançon, France

  5. 5

    Centre d'Investigation Clinique, Centre Hospitalier Universitaire Jean Minjoz, Besançon, France

  6. 6

    Service d'Hépatogastroenterologie, Centre Hospitalier Universitaire du Bocage, Dijon, France

  1. †

    Telephone: 33 381668421; FAX: 33 381668417

*Service d'Hépatologie, Centre Hospitalier Universitaire Jean Minjoz, 25000 Besançon, France

Publication History

  1. Issue published online: 26 JUN 2009
  2. Article first published online: 26 JUN 2009
  3. Manuscript Accepted: 11 MAR 2009
  4. Manuscript Received: 11 DEC 2008

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Abstract

Acute graft-versus-host disease (GVHD) following orthotopic liver transplantation is a rare but severe disease with a 75% death rate in adults. Various therapeutic strategies have been proposed for steroid-refractory GVHD, but there is still no consensus. Tumor necrosis factor-alpha is a key inflammatory cytokine involved in acute GVHD physiopathology, and infliximab has shown encouraging results for the treatment of acute GVHD following hematopoietic stem cell transplantation. We report the first case of acute GVHD following liver transplantation that was refractory to steroids and anti-lymphocyte globulin but was successfully treated with infliximab. Liver Transpl 15:682–685, 2009. © 2009 AASLD.

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