Telephone: 214-820-8500; FAX: 214-820-8168
Original Articles
You have full text access to this OnlineOpen article
Conivaptan increases serum sodium in hyponatremic patients with end-stage liver disease
Article first published online: 29 SEP 2009
DOI: 10.1002/lt.21836
Copyright © 2009 American Association for the Study of Liver Diseases
Additional Information
How to Cite
O'Leary, J. G. and Davis, G. L. (2009), Conivaptan increases serum sodium in hyponatremic patients with end-stage liver disease. Liver Transpl, 15: 1325–1329. doi: 10.1002/lt.21836
Publication History
- Issue published online: 29 SEP 2009
- Article first published online: 29 SEP 2009
- Manuscript Accepted: 11 MAY 2009
- Manuscript Received: 18 NOV 2008
REFERENCES
- 1, , , , , , et al. MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation. Gut 2007; 56: 1283–1290.
- 2, , , , , , et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008; 359: 1018–1026.
- 3, , , , , , et al. Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death. Hepatology 2004; 40: 802–810.
- 4, , , , , . Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone. Liver Transpl 2005; 11: 336–343.Direct Link:
- 5, , , , , , et al. Model for End-Stage Liver Disease (MELD) and allocation of donor livers. Gastroenterology 2003; 124: 91–96.
- 6, , , , , , et al. Hyponatremia impairs early posttransplantation outcome in patients with cirrhosis undergoing liver transplantation. Gastroenterology 2006; 130: 1135–1143.
- 7, , , . The impact of serum sodium concentration on mortality after liver transplantation: a cohort multicenter study. Liver Transpl 2007; 13: 1115–1124.Direct Link:
- 8, , , , , . Central nervous system complications in liver transplant recipients—incidence, timing, and long-term follow-up. Clin Transplant 2000; 14: 1–7.Direct Link:
- 9, , , . Incidence and etiology of hyponatremia in an intensive care unit. Clin Nephrol 1990; 34: 163–166.
- 10, . Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management. Hepatology 2008; 48: 1002–1010.Direct Link:
- 11, , , , , , . Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med 2006; 355: 2099–2112.
- 12, , , , , . Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial. Hepatology 2008; 48: 204–213.Direct Link:
- 13, , , . Pharmacodynamic effects of a nonpeptide antidiuretic hormone V2 antagonist in cirrhotic patients with ascites. Hepatology 2002; 36: 1197–1205.Direct Link:
- 14, , , , , , . Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial. Gastroenterology 2003; 124: 933–939.
- 15, , , . A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial. Hepatology 2003; 37: 182–191.Direct Link:
- 16, , , , , , et al. Therapeutic and diagnostic potential of a vasopressin-2 antagonist for impaired water handling in cirrhosis. Clin Pharmacol Ther 1998; 63: 561–570.
- 17, , , , , , et al. Oral V2 receptor antagonist (RWJ-351647) in patients with cirrhosis and ascites: a randomized, double-blind, placebo-controlled, single ascending dose study. Aliment Pharmacol Ther 2006; 24: 973–982.Direct Link:
- 18, , , , , , et al. Hyponatremia in cirrhosis: from pathogenesis to treatment. Hepatology 1998; 28: 851–864.Direct Link:
- 19, , , . Hyponatremia in cirrhosis: results of a patient population survey. Hepatology 2006; 44: 1535–1542.Direct Link:

1527-6473/asset/LT_left.gif?v=1&s=e1df7d33719b841a3479d2fd0a24baa5df4653e4)
1527-6473/asset/LT_right.gif?v=1&s=5deda9b4c4c603398e58a7274cf47e5b03ffc5fe)
1527-6473/asset/cover.gif?v=1&s=8c6a04b26832399220fbb731e05bd8cc9ff13ae2)