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Long-term outcomes in pediatric liver transplantation
Article first published online: 29 OCT 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Supplement: ILTS/AASLD Transplant Course: Long-Term Outcomes of Adult and Pediatric Liver Transplantation
Volume 15, Issue Supplement S2, pages S6–S11, November 2009
How to Cite
Bucuvalas, J. (2009), Long-term outcomes in pediatric liver transplantation. Liver Transpl, 15: S6–S11. doi: 10.1002/lt.21915
- Issue published online: 29 OCT 2009
- Article first published online: 29 OCT 2009
- Manuscript Accepted: 3 SEP 2009
- Manuscript Received: 1 MAY 2009
1. Critical clinical outcomes for pediatric liver transplantation (LT) recipients include (1) patient and graft survival, (2) complications (immune and nonimmune) of chronic immunosuppressive medications, and (3) long-term graft function.
2. Recurrence of malignancy, sepsis, and posttransplant lymphoproliferative disorder account for more than 65% of deaths occurring more than 1 year after LT.
3. Chronic rejection, late hepatic artery thrombosis, and biliary strictures account for 70% of graft loss occurring more than 1 year after LT.
4. Late histological changes in the allograft are emerging as a common problem in patients more than 5 years after LT. The pathogenesis of these findings and the impact on graft survival remain to be determined. Liver Transpl 15:S6–S11, 2009. © 2009 AASLD.