Telephone: 410-614-8297; FAX: 410-614-7649
Increased risk of graft loss from hepatic artery thrombosis after liver transplantation with older donors†
Article first published online: 24 NOV 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 15, Issue 12, pages 1688–1695, December 2009
How to Cite
Stewart, Z. A., Locke, J. E., Segev, D. L., Dagher, N. N., Singer, A. L., Montgomery, R. A. and Cameron, A. M. (2009), Increased risk of graft loss from hepatic artery thrombosis after liver transplantation with older donors. Liver Transpl, 15: 1688–1695. doi: 10.1002/lt.21946
The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
- Issue published online: 24 NOV 2009
- Article first published online: 24 NOV 2009
- Manuscript Accepted: 11 SEP 2009
- Manuscript Received: 17 OCT 2008
- The United Network for Organ Sharing National Data Registry is supported in part by Health Resources and Services Administration. Grant Number: 231-00-0115
Hepatic artery thrombosis (HAT) is the most common vascular complication after liver transplantation; it has been reported to occur in 2% to 5% of liver transplant recipients. Most reports of HAT in the literature describe single-center series with small numbers of patients and lack the power to definitively identify nontechnical risk factors. We used the United Network for Organ Sharing database of adult deceased donor liver transplants from 1987 to 2006 to identify 1246 patients with graft loss from HAT. Univariate and multivariate regression analyses were performed to identify donor and graft risk factors for HAT-induced graft loss. Although most donor predictors of HAT-induced graft loss were surrogates for vessel size, donor age > 50 years was also a significant predictor of graft loss from HAT (relative risk = 1.45, P < 0.001). Furthermore, the risk of graft loss from HAT increased progressively with each decade of donor age > 50 years, such that a 61% increased risk of HAT-related graft loss (relative risk = 1.61, P < 0.001) was associated with donor age > 70 years. A separate analysis of risk factors for early HAT graft loss (≤90 days) and late HAT graft loss (> 90 days) found that older donor age was associated with increased late HAT graft loss. These findings are of interest in an era of ongoing organ shortages requiring maximum utilization of potential allografts and increasing allocation of older allografts. Liver Transpl 15:1688–1695, 2009. © 2009 AASLD.