Telephone: 00390503152216; FAX: 00390503152166
Religiosity associated with prolonged survival in liver transplant recipients†
Article first published online: 3 SEP 2010
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 16, Issue 10, pages 1158–1163, October 2010
How to Cite
Bonaguidi, F., Michelassi, C., Filipponi, F. and Rovai, D. (2010), Religiosity associated with prolonged survival in liver transplant recipients. Liver Transpl, 16: 1158–1163. doi: 10.1002/lt.22122
This study was performed with institutional grants from the Institute of Clinical Physiology of the National Research Council.
- Issue published online: 18 JUN 2010
- Article first published online: 3 SEP 2010
- Accepted manuscript online: 18 JUN 2010 12:00AM EST
- Manuscript Accepted: 5 JUN 2010
- Manuscript Received: 17 FEB 2010
We tested the hypothesis that religiosity (ie, seeking God's help, having faith in God, trusting in God, and trying to perceive God's will in the disease) is associated with improved survival in patients with end-stage liver disease who have undergone orthotopic liver transplantation. We studied a group of 179 candidates for liver transplantation who responded to a questionnaire on religiosity during the pretransplant psychological evaluation and underwent transplantation between 2004 and 2007. The demographic data, educational level, employment status, clinical data, and results of the questionnaire were compared with the survival of patients during follow-up, regardless of the cause of any deaths. Factorial analysis of responses to the questionnaire revealed 3 main factors: searching for God (active), waiting for God (passive), and fatalism. The consistency of the matrix was very high (consistency index = 0.92). Eighteen patients died during follow-up (median time = 21 months). In multivariate analysis, only the searching for God factor [hazard ratio (HR) = 2.95, 95% confidence interval (CI) = 1.05-8.32, χ2 = 4.205, P = 0.040] and the posttransplant length of stay in the intensive care unit (HR = 1.05, 95% CI = 1.01-1.08, χ2 = 8.506, P = 0.035) were independently associated with survival, even after adjustments for the waiting for God factor, fatalism, age, sex, marital status, employment, educational level, viral etiology, Child-Pugh score, serum creatinine level, time from the questionnaire to transplantation, donor age, and intraoperative bleeding. Patients who did not present the searching for God factor were younger than those who did, but they had shorter survival times (P = 0.037) and a 3-fold increased relative risk of dying (HR = 3.01, 95% CI = 1.07-8.45). In conclusion, religiosity is associated with prolonged survival in patients undergoing liver transplantation. Liver Transpl, 2010. © 2010 AASLD.