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Cytomegalovirus infection after liver transplantation†
Article first published online: 5 OCT 2010
Copyright © 2010 American Association for the Study of Liver Diseases
Supplement: Liver Transplantation - State of the Science
Volume 16, Issue Supplement S2, pages S45–S53, October 2010
How to Cite
Razonable, R. R. (2010), Cytomegalovirus infection after liver transplantation. Liver Transpl, 16: S45–S53. doi: 10.1002/lt.22144
Potential conflict of interest: Nothing to report.
- Issue published online: 5 OCT 2010
- Article first published online: 5 OCT 2010
- Manuscript Accepted: 14 JUL 2010
- Manuscript Received: 8 JUN 2010
1. Cytomegalovirus (CMV) is a common infection after liver transplantation and manifests as an asymptomatic infection or clinically as CMV syndrome (fever and myelosuppression) or tissue-invasive CMV disease.
2. The most common risk factor for CMV disease is donor positivity and recipient negativity for CMV, and severe impairment in immunity, especially with a pathogen-specific immune response, generally predisposes patients to CMV disease after transplantation.
3. The prevention of CMV disease after liver transplantation consists of preemptive therapy (antiviral therapy is administered only in the presence of a positive CMV polymerase chain reaction or pp65 antigenemia) or antiviral prophylaxis (an antiviral drug is administered to all patients at risk of CMV disease).
4. The treatment of CMV disease consists of intravenous ganciclovir (for severe disease) or oral valganciclovir (for mild to moderate CMV disease). Liver Transpl 16:S45-S53, 2010. © 2010 AASLD.