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Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation: The effect of smoking withdrawal†
Article first published online: 28 MAR 2011
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 17, Issue 4, pages 402–408, April 2011
How to Cite
Herrero, J. I., Pardo, F., D'Avola, D., Alegre, F., Rotellar, F., Iñarrairaegui, M., Martí, P., Sangro, B. and Quiroga, J. (2011), Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation: The effect of smoking withdrawal. Liver Transpl, 17: 402–408. doi: 10.1002/lt.22247
The Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas is funded by the Instituto de Salud Carlos III.
- Issue published online: 28 MAR 2011
- Article first published online: 28 MAR 2011
- Accepted manuscript online: 10 JAN 2011 09:03AM EST
- Manuscript Accepted: 6 DEC 2010
- Manuscript Received: 22 JUL 2010
Liver transplant recipients have an increased risk of malignancy. Smoking is related to some of the most frequent causes of posttransplant malignancy. The incidence and risk factors for the development of neoplasia related to smoking (head and neck, lung, esophageal, and kidney and urinary tract carcinomas) were studied in 339 liver transplant recipients. Risk factors for the development of smoking-related neoplasia were also studied in 135 patients who had a history of smoking so that it could be determined whether smoking withdrawal was associated with a lower risk of malignancy. After a mean follow-up of 7.5 years, 26 patients were diagnosed with 29 smoking-related malignancies. The 5- and 10-year actuarial rates were 5% and 13%, respectively. In multivariate analysis, smoking and older age were independently associated with a higher risk of malignancy. In the smoker subgroup, the variables related to a higher risk of malignancy were active smoking and older age. In conclusion, smoking withdrawal after liver transplantation may have a protective effect against the development of neoplasia. Liver Transpl, 2011. © 2011 AASLD.