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Transjugular intrahepatic portosystemic shunt for the treatment of sinusoidal obstruction syndrome in a liver transplant recipient and review of the literature

  1. Isabel Campos-Varela1,7,8,†,*,
  2. Lluís Castells1,7,8,
  3. Cristina Dopazo2,
  4. Mercedes Pérez-Lafuente3,
  5. Helena Allende4,
  6. Oscar Len5,
  7. Lluís Llopart6,
  8. Victor Vargas1,7,8,
  9. Ramón Charco2

Article first published online: 25 JAN 2012

DOI: 10.1002/lt.22351

Issue

Liver Transplantation

Liver Transplantation

Volume 18, Issue 2, pages 201–205, February 2012

Additional Information

How to Cite

Campos-Varela, I., Castells, L., Dopazo, C., Pérez-Lafuente, M., Allende, H., Len, O., Llopart, L., Vargas, V. and Charco, R. (2012), Transjugular intrahepatic portosystemic shunt for the treatment of sinusoidal obstruction syndrome in a liver transplant recipient and review of the literature. Liver Transpl, 18: 201–205. doi: 10.1002/lt.22351

Author Information

  1. 1

    Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d' Hebron, Institut de Recerca (VHIR), Barcelona, Spain

  2. 2

    Liver Transplant Unit, Department of HPB-Surgery and Transplant, Hospital Universitari Vall d' Hebron, Institut de Recerca (VHIR), Barcelona, Spain

  3. 3

    Radiology Department, Hospital Universitari Vall d' Hebron, Institut de Recerca (VHIR), Barcelona, Spain

  4. 4

    Pathology Department, Hospital Universitari Vall d' Hebron, Institut de Recerca (VHIR), Barcelona, Spain

  5. 5

    Infectious Diseases Department, Hospital Universitari Vall d' Hebron, Institut de Recerca (VHIR), Barcelona, Spain

  6. 6

    Critical Care Department, Hospital Universitari Vall d' Hebron, Institut de Recerca (VHIR), Barcelona, Spain

  7. 7

    Centro de Investigación Biomedica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)

  8. 8

    Universitat Autónoma de Barcelona, Departament de Medicina

  1. †

    Telephone: 34.93.274.61.40; FAX: 34.93.274.60.68

*Department of Internal Medicine (Liver Unit), Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, Barcelona, Spain 08035

  1. †

    Telephone: 34.93.274.61.40; FAX: 34.93.274.60.68

Publication History

  1. Issue published online: 25 JAN 2012
  2. Article first published online: 25 JAN 2012
  3. Accepted manuscript online: 7 JUN 2011 01:24PM EST
  4. Manuscript Accepted: 25 MAY 2011
  5. Manuscript Received: 8 FEB 2011

Funded by

  • Celine Cavallo for English language edition and Esther Delgado for her secretarial work

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Abstract

Sinusoidal obstruction syndrome (SOS) is a rare, life-threatening clinical syndrome resulting from sinusoidal congestion, and it is characterized by hepatomegaly, ascites, weight gain, and jaundice. The frequency of this condition after liver transplantation (LT) is low, but when SOS is severe and refractory to medical therapy, the ultimate solution is retransplantation. We describe a patient with SOS after LT who was successfully treated by the placement of a transjugular intrahepatic portosystemic shunt (TIPS). Although information on this approach is scarce because of the low incidence of SOS in LT patients, we review the available literature on treating this condition with a TIPS. On the basis of the reported information and our patient's outcome, we suggest that prompt TIPS placement can be considered for SOS when medical treatment fails. Nonetheless, a formal assessment and prospective studies are needed to confidently indicate TIPS placement in this situation. Liver Transpl 18:201–205, 2012. © 2011 AASLD.

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