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Assist devices: Machine preservation of extended criteria donors

Authors

  • James V. Guarrera

    Corresponding author
    1. Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, New York, NY
    • Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH 14 Center, Room 202, New York, NY 10032
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    • Telephone: 212-305-4199; FAX: 212-305-8710


  • Potential conflict of interest: Nothing to report.

Abstract

Key Points

1. Hypothermic machine perfusion (HMP) is in its infancy in clinical liver transplantation. Potential benefits include diminished preservation injury (PI) and improved graft function.

2. We have employed HMP in 21 extended criteria donor (ECD livers) at our center with excellent clinical outcomes.

3. Our experience with liver HMP is the only reported clinical experience worldwide representing a total of 41 successful liver transplant cases showing improved outcomes and diminished markers of ischemia/reperfusion injury.

4. Further multicenter and large scale trials are now warranted to further explore the benefits and applicability of liver HMP into the clinical mainstream. Liver Transpl, 2012. © 2012 AASLD.

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