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Optimizing outcomes for pediatric recipients†
Article first published online: 26 OCT 2012
Copyright © 2012 American Association for the Study of Liver Diseases
Supplement: Reaching the Summit: Challenges and Obstacles in Liver Transplantation
Volume 18, Issue Supplement S2, pages S34–S38, November 2012
How to Cite
Samyn, M. (2012), Optimizing outcomes for pediatric recipients. Liver Transpl, 18: S34–S38. doi: 10.1002/lt.23543
Potential conflict of interest: Nothing to report.
- Issue published online: 26 OCT 2012
- Article first published online: 26 OCT 2012
- Accepted manuscript online: 1 SEP 2012 03:49AM EST
- Manuscript Accepted: 29 AUG 2012
- Manuscript Received: 12 JUN 2012
1. After liver transplantation (LT), the majority of children now grow into adulthood, with 10-year patient survival rates of 74% to 84% and graft survival rates of 62% to 72% according to United Network for Organ Sharing data.
2. Graft and patient survival rates decrease for patients undergoing transplantation between the ages of 12 and 17 years, and this raises the importance of dedicated adolescent care and appropriate transitioning to adult services.
3. Complications associated with long-term immunosuppression, including renal complications, infections, malignancies, and cardiovascular complications, are well described, and the risk factors are defined.
4. Biomarkers for measuring clinical immunosuppression and the concept of tolerance-inducing regimens are exciting, but further assessment is needed in large, prospective, multicenter studies.
5. As long-term medical complications are better managed, we need to focus on understanding the challenges for pediatric LT patients with respect to quality of life and health status. Liver Transpl, 2012. © 2012 AASLD.