The Adult-to-Adult Living Donor Liver Transplantation Cohort Study includes Northwestern University (Chicago, IL), the University of California Los Angeles (Los Angeles, CA), the University of California San Francisco (San Francisco, CA), the University of Colorado Health Sciences Center (Denver, CO), the University of North Carolina (Chapel Hill, NC), the Division of Digestive Diseases and Nutrition (Epidemiology and Clinical Trials Branch) of the National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, MD), the University of Michigan (Ann Arbor, MI), the Department of Surgery of Columbia Presbyterian Medical Center (New York, NY), the University of Pennsylvania (Philadelphia, PA), the Department of Internal Medicine at the University of Virginia (Charlottesville, VA), and Virginia Commonwealth University (Richmond, VA). This is publication 21 of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.
Development, management, and resolution of biliary complications after living and deceased donor liver transplantation: A report from the adult-to-adult living donor liver transplantation cohort study consortium
Article first published online: 11 MAR 2013
Copyright © 2013 American Association for the Study of Liver Diseases
Volume 19, Issue 3, pages 259–267, March 2013
How to Cite
Zimmerman, M. A., Baker, T., Goodrich, N. P., Freise, C., Hong, J. C., Kumer, S., Abt, P., Cotterell, A. H., Samstein, B., Everhart, J. E. and Merion, R. M. (2013), Development, management, and resolution of biliary complications after living and deceased donor liver transplantation: A report from the adult-to-adult living donor liver transplantation cohort study consortium. Liver Transpl, 19: 259–267. doi: 10.1002/lt.23595
Michael A. Zimmerman, Nathan P. Goodrich, Benjamin Samstein, Peter Abt, Johnny C. Hong, Talia Baker, Robert M. Merion, and Chris Freise receive funding from the National Institutes of Health; they have no other conflicts of interests to declare. Sean Kumer, Adrian H. Cotterell, and James E. Everhart have no conflicts of interests to declare.
The patients participating in this trial were enrolled in the National Institutes of Health–sponsored Adult-to-Adult Living Donor Liver Transplantation Cohort Study. This study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases through cooperative agreements (grants U01-DK62536, U01-DK62444, U01-DK62467, U01-DK62483, U01-DK62484, U01-DK62494, U01-DK62496, U01-DK62498, U01-DK62505, and U01-DK62531). The trial was also funded by research grants from Schering-Plough through a cooperative research and development agreement with the National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health and through a clinical trial agreement between Ortho-Biotech and the National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health. Additional support was provided by the Health Resources and Services Administration and the American Society of Transplant Surgeons.
- Issue published online: 11 MAR 2013
- Article first published online: 11 MAR 2013
- Manuscript Accepted: 11 DEC 2012
- Manuscript Received: 17 OCT 2012
Adult recipients of living donor liver transplantation (LDLT) have a higher incidence of biliary complications than recipients of deceased donor liver transplantation (DDLT). Our objective was to define the intensity of the interventions and the time to resolution after the diagnosis of biliary complications after liver transplantation. We analyzed the management and resolution of posttransplant biliary complications and investigated the comparative effectiveness of interventions in LDLT and DDLT recipients. For the analysis of biliary complications (leaks or strictures), we used a retrospective cohort of patients who underwent liver transplantation at 8 centers between 1998 and 2006 (median follow-up from onset=4.7 years). The numbers, procedure types, and times to resolution were compared for LDLT and DDLT recipients. Posttransplant biliary complications occurred in 47 of the 189 DDLT recipients (25%) and in 141 of the 356 LDLT recipients (40%). Biliary leaks constituted 38% of the post-DDLT biliary complications (n=18) and 65% of the post-LDLT biliary complications (n=91). The median times to first biliary complications were similar for DDLT and LDLT (11 versus 14 days for leaks, P=0.63; 69 versus 107 days for strictures, P=0.34). Overall, 1225 diagnostic and therapeutic procedures, including reoperation and retransplantation, were performed (6.5±5.4 per recipient; 5.5±3.6 for DDLT versus 6.8±5.8 for LDLT, P=0.52). The median number of months to the resolution of a biliary complication (i.e., a tube-, stent-, and drain-free status) did not significantly differ between the DDLT and LDLT groups for leaks (2.3 versus 1.3 months, P=0.29) or strictures (4.9 versus 2.3 months, P=0.61). Although the incidence of biliary complications is higher after LDLT versus DDLT, the treatment requirements and the time to resolution after the development of a biliary complication are similar for LDLT and DDLT recipients. Liver Transpl 19:259–267, 2013. © 2013 AASLD.