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Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation
Article first published online: 22 MAR 2013
Copyright © 2013 American Association for the Study of Liver Diseases
Volume 19, Issue 4, pages 383–394, April 2013
How to Cite
Joshi, D., Salehi, S., Brereton, H., Arno, M., Quaglia, A., Heaton, N., O'Grady, J., Agarwal, K. and Aluvihare, V. (2013), Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation. Liver Transpl, 19: 383–394. doi: 10.1002/lt.23613
This project was supported by the National Health Service Charity of King's College Hospital.
- Issue published online: 27 MAR 2013
- Article first published online: 22 MAR 2013
- Accepted manuscript online: 13 FEB 2013 12:51PM EST
- Manuscript Accepted: 23 DEC 2012
- Manuscript Received: 24 SEP 2012
Additional Supporting Information may be found in the online version of this article.
|lt23613-sup-0001-supptab1.doc||147K||Supporting Table 1. List of miRNA and associated P values for A-D analysis (Figure 2A main text, P<.01). * Multiple entries denote cross-species miRNA with sequence homology.|
|lt23613-sup-0002-supptab2.doc||125K||Supporting Table 2. List of miRNA and associated P values for A v B analysis (Supporting Figure 2A, P<.01)|
|lt23613-sup-0003-supptab3.doc||150K||Supporting Table 3. List of miRNA and associated P values for B v C analysis (Figure 5, P<.01). * Includes cross species miRNA|
|lt23613-sup-0004-suppfig1.tif||2725K||Supporting Figure 1: Consort diagram of patient selection. * HCV patients undergoing primary liver transplantation only ** Patients excluded; fibrosing cholestatic recurrence of HCV (n=10), undergoing re-liver transplantation (n=13), hepatocellular carcinoma (n=62), co-infection with HIV (n = 8), co-infection with HBV (n= 12), joint liver-kidney transplantation (n=1), survival less than 12 months (n=35), no 12 month liver biopsy available (n=25). *** Patients were matched according to recipient age, donor age, MELD score at transplant, viral genotype, donor-risk-index, cold-ischemia time, presence of diabetes, evidence of CMV viremia and immunosuppression regimen.|
|lt23613-sup-0005-suppfig2.tif||579K||Supporting Figure 2: miRNA expression distinguishes slow and fast progressors of HCV post transplant. (A) Hierarchical cluster analysis and cladogram for Groups A and B (P<.01). (B) Principal Component Analysis for the same data-set. miRNA list and associated P values shown in Supporting Table 2.|
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