These authors were joint senior authors.
Role of Toll-Like Receptor 4 in Mediating Multiorgan Dysfunction in Mice With Acetaminophen Induced Acute Liver Failure
Article first published online: 25 JUN 2013
© 2013 American Association for the Study of Liver Diseases
Volume 19, Issue 7, pages 751–761, July 2013
How to Cite
Shah, N., Montes de Oca, M., Jover-Cobos, M., Tanamoto, K.-i., Muroi, M., Sugiyama, K.-i., Davies, N. A., Mookerjee, R. P., Dhar, D. K. and Jalan, R. (2013), Role of Toll-Like Receptor 4 in Mediating Multiorgan Dysfunction in Mice With Acetaminophen Induced Acute Liver Failure. Liver Transpl, 19: 751–761. doi: 10.1002/lt.23655
- Issue published online: 25 JUN 2013
- Article first published online: 25 JUN 2013
- Accepted manuscript online: 2 APR 2013 03:55AM EST
- Manuscript Accepted: 28 MAR 2013
- Manuscript Received: 20 NOV 2012
Additional Supporting Information may be found in the online version of this article.
|lt23655-sup-0001-suppinfo.tif||666K||Supporting Figure 1: TLR4 signalling Represents the adaptors involved in TLR4 signalling and the site of action of STM28 (TLR4 antagonist).|
|lt23655-sup-0002-suppinfo.tif||995K||Supporting Figure 2: Percentage of Dendritic cells, B lymphocytes, T-lymphocytes and NK cells in APAP and APAP+STM28 group. There were no changes seen in the cell subtypes. Panels represent the dendritic cells, B lymphocytes, T lymphocytes and the NK cells.|
|lt23655-sup-0003-suppinfo.tif||1940K||Supporting Figure 3: Organ cross talk in Acute liver failure: Represents the inflammatory cascade following the release of DAMP's and the subsequent effect on the end organ function involving TLR4 pathway.|
Supporting Table 1: Surface phenotypic markers used to identify immune cells.
Supporting Table 2: Staging and grading of necrosis and Kupffer cells in the APAP+STM28 group and TLR4 KO group.
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