Additional Supporting Information may be found in the online version of this article.

lt23655-sup-0001-suppinfo.tif666KSupporting Figure 1: TLR4 signalling Represents the adaptors involved in TLR4 signalling and the site of action of STM28 (TLR4 antagonist).
lt23655-sup-0002-suppinfo.tif995KSupporting Figure 2: Percentage of Dendritic cells, B lymphocytes, T-lymphocytes and NK cells in APAP and APAP+STM28 group. There were no changes seen in the cell subtypes. Panels represent the dendritic cells, B lymphocytes, T lymphocytes and the NK cells.
lt23655-sup-0003-suppinfo.tif1940KSupporting Figure 3: Organ cross talk in Acute liver failure: Represents the inflammatory cascade following the release of DAMP's and the subsequent effect on the end organ function involving TLR4 pathway.

Supporting Table 1: Surface phenotypic markers used to identify immune cells.

Supporting Table 2: Staging and grading of necrosis and Kupffer cells in the APAP+STM28 group and TLR4 KO group.

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