There is no financial or grant support to report for this work, and none of the authors have any relevant conflicts of interest to disclose.
Physical activity and metabolic syndrome in liver transplant recipients
Article first published online: 15 AUG 2013
Copyright © 2013 American Association for the Study of Liver Diseases
Volume 19, Issue 10, pages 1125–1131, October 2013
How to Cite
Kallwitz, E. R., Loy, V., Mettu, P., Von Roenn, N., Berkes, J. and Cotler, S. J. (2013), Physical activity and metabolic syndrome in liver transplant recipients. Liver Transpl, 19: 1125–1131. doi: 10.1002/lt.23710
- Issue published online: 24 SEP 2013
- Article first published online: 15 AUG 2013
- Accepted manuscript online: 25 JUL 2013 02:55PM EST
- Manuscript Accepted: 30 JUN 2013
- Manuscript Received: 17 APR 2013
There is a high prevalence of metabolic syndrome in liver transplant recipients, a population that tends to be physically inactive. The aim of this study was to characterize physical activity and evaluate the relationship between physical activity and metabolic syndrome after liver transplantation. A cross-sectional analysis was performed in patients more than 3 months after transplantation. Metabolic syndrome was classified according to National Cholesterol Education Panel Adult Treatment Panel III guidelines. Physical activity, including duration, frequency, and metabolic equivalents of task (METs), was assessed. The study population consisted of 204 subjects, with 156 more than 1 year after transplantation. The median time after transplantation was 53.5 months (range = 3-299 months). The mean duration of exercise was 90 ± 142 minutes, and the mean MET score was 3.6 ± 1.5. Metabolic syndrome was observed in 58.8% of all subjects and in 63.5% of the subjects more than 1 year after transplantation. In a multivariate analysis involving all subjects, metabolic syndrome was associated with a time after transplantation greater than 1 year [odds ratio (OR) = 2.909, 95% confidence interval (CI) = 1.389-6.092] and older age (OR = 1.036, 95% CI = 1.001-1.072). A second analysis was performed for only patients more than 1 year after transplantation. In a multivariate analysis, metabolic syndrome was associated with lower exercise intensity (OR = 0.690, 95% CI = 0.536-0.887), older age (OR = 1.056, 95% CI = 1.014-1.101), and pretransplant diabetes (OR = 4.246, 95% CI = 1.300-13.864). In conclusion, metabolic syndrome is common after liver transplantation, and the rate is significantly higher in patients more than 1 year after transplantation. The observation that exercise intensity is inversely related to metabolic syndrome after transplantation is novel and suggests that physical activity might provide a means for reducing metabolic syndrome complications in liver transplant recipients. Liver Transpl 19:1125–1131, 2013. © 2013 AASLD.