This research was supported in part by the Julie Henry Research Fund and the Center for Transplant Outcomes and Quality Improvement of the Transplant Institute at Beth Israel Deaconess Medical Center.
Substance abuse treatment and its association with relapse to alcohol use after liver transplantation
Article first published online: 21 OCT 2013
© 2013 American Association for the Study of Liver Diseases
Volume 19, Issue 12, pages 1387–1395, December 2013
How to Cite
Rodrigue, J. R., Hanto, D. W. and Curry, M. P. (2013), Substance abuse treatment and its association with relapse to alcohol use after liver transplantation. Liver Transpl, 19: 1387–1395. doi: 10.1002/lt.23747
The authors have no conflicts of interest to disclose.
- Issue published online: 27 NOV 2013
- Article first published online: 21 OCT 2013
- Accepted manuscript online: 1 OCT 2013 06:55AM EST
- Manuscript Accepted: 31 AUG 2013
- Manuscript Received: 22 MAR 2013
- The Julie Henry Research Fund
- The Center for Transplant Outcomes and Quality Improvement of the Transplant Institute at Beth Israel Deaconess Medical Center
Many liver transplantation (LT) programs require substance abuse (SA) treatment for candidates with a history of alcohol abuse. However, there are no data indicating that SA treatment prevents post-LT alcohol relapse. We examined 118 adults who underwent LT from May 2002 to February 2011 to explore the relationship between SA treatment and post-LT relapse to any alcohol use. Sixty-one patients (52%) with a history of alcohol abuse or dependence received SA treatment before LT. Relapse to any alcohol use was identified in 40 LT recipients (34%). Patients who received SA treatment before LT did not differ significantly in the rate of post-LT alcohol relapse from patients who did not receive treatment before transplantation (30% versus 39%, P = 0.20). However, patients who received SA treatment both before and after transplantation had significantly lower rates of alcohol relapse (16%) than patients who received no SA treatment (41%) or SA treatment only before LT (45%, P = 0.03). Our findings suggest that LT programs should consider placing more emphasis on the continuation of some type of SA treatment after transplantation. Future research should prospectively examine the optimal timing for SA treatment that will attenuate the risk of alcohol relapse after transplantation. Liver Transpl 19:1387–1395, 2013. © 2013 AASLD.