De novo hepatocellular carcinoma in a hepatic allograft with recurrent hepatitis C cirrhosis

Authors

  • Romil Saxena,

    1. Lillian and Henry M. Stratton-Hans Popper Department of Pathology, The Mount Sinai Medical Center of the City University of New York, NY
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  • Ming Q. Ye,

    1. Lillian and Henry M. Stratton-Hans Popper Department of Pathology, The Mount Sinai Medical Center of the City University of New York, NY
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  • Sukru Emre,

    1. Abdominal Organ Transplant of the Department of Surgery, The Mount Sinai Medical Center of the City University of New York, NY
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  • Franklin Klion,

    1. Liver Diseases of the Department of Medicine, The Mount Sinai Medical Center of the City University of New York, NY
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  • Michael A. Nalesnik,

    1. Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
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  • Swan N. Thung

    Corresponding author
    1. Lillian and Henry M. Stratton-Hans Popper Department of Pathology, The Mount Sinai Medical Center of the City University of New York, NY
    • Address reprint requests to Swan N. Thung, MD, Department of Pathology, Box 1194, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029
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Abstract

We report a case of de novo hepatocellular carcinoma (HCC) in a patient with recurrent hepatitis C (HCV) and cirrhosis 7 years after orthotopic liver transplantation (OLT). This is a previously unreported observation in the natural history of posttransplantantion HCV infection and reiterates the strong oncogenic potential of HCV.

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