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Erosion Induced Controllable Release of Gliclazide Encapsulated Inside Degradable Polymeric Particles

  1. Yue Zhao1,2,
  2. Wenna Chen2,
  3. Qing Cai2,
  4. Shenguo Wang2,
  5. Jun Bo3,
  6. Chi Wu1,4,*

Article first published online: 15 MAR 2004

DOI: 10.1002/mabi.200300061

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Special Issue: Highlights from the First IUPAC International Conference on Bio-based Polymers (ICBP 2003) in Saitama, Japan

Volume 4, Issue 3, pages 308–313, March 15, 2004

Additional Information

How to Cite

Zhao, Y., Chen, W., Cai, Q., Wang, S., Bo, J. and Wu, C. (2004), Erosion Induced Controllable Release of Gliclazide Encapsulated Inside Degradable Polymeric Particles. Macromol. Biosci., 4: 308–313. doi: 10.1002/mabi.200300061

Author Information

  1. 1

    The Open Laboratory of Bond-selective Chemistry, Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, China, 230026

  2. 2

    State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Science, Beijing 100080, P. R. China

  3. 3

    Anhui Medical Institute, Hefei, Anhui, China, 230000

  4. 4

    Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

*Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Fax: 0086 852 2603 5057

Publication History

  1. Issue published online: 15 MAR 2004
  2. Article first published online: 15 MAR 2004
  3. Manuscript Accepted: 16 JAN 2004
  4. Manuscript Revised: 12 JAN 2004
  5. Manuscript Received: 2 OCT 2003

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Keywords:

  • colloids;
  • controllable drug releasing;
  • light scattering;
  • micronization;
  • polyesters

Abstract

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Summary: The microphase inversion of water-insoluble poly(L-lactide), “poly[(L-lactide)-co-glycolide] and polylactide-block-poly(ethylene oxide)-block-polylactide from THF to water can result in narrowly distributed stable particles. Gliclazide, a commercial drug, can be encapsulated inside during the process. The formation and degradation of such particles was studied by laser light scattering. In comparison with the corrosion of a bulk material, the degradation of each particle is so fast that we only detect the decrease of the particle number, not the corrosion of individual particles. Therefore, the degradation is a “one-by-one” random process, just like the chemical reaction of molecules in solution. The disappearing rate of the particle number is nearly independent of time, ideal for the controlled release of drugs encapsulated inside. The amount of encapsulated gliclazide depends on the copolymer's hydrophobicity (composition), while the releasing rate mainly is, directly related to the disappearing rate of the particles. The correlation between the fluorescence intensity and the degradation was used to study the kinetics of gliclazide releasing. The releasing pattern is controllable with a proper choice of the drug loading, copolymer composition, pH and temperature.

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